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[资源] 合成与植物化学结合的方向Diversity-Oriented Synthesis

The gap between insights into human disease and therapeutics that arise from these
insights is closing, but it cannot close fast enough. Society has patiently invested in
science. But its expectation of scientists—that we mitigate suffering from disease—
must be met if we expect to receive its support in the future.
Advances in human biology are revealing novel insights into the cause of disease
and requirements for the maintenance of disease. But the therapeutic targets that are
arising, such as transcription factors and RNA molecules, do not fit conveniently
into what we believe is currently achievable in drug discovery. Overcoming this
belief is the twenty-first century challenge for organic chemistry, organic synthesis,
and chemical biology. If we can do so, drug discovery and human health will be
transformed.
The insights provided in Diversity-Oriented Synthesis: Basics and Applications
in Organic Synthesis, Drug Discovery, and Chemical Biology leave me feeling optimistic.
I can sense the fearlessness and audacity of the authors as they undertake
the impossible. The three-dimensional world of biological macromolecules is now
interfaced with the three-dimensional world of small molecules to a far greater
degree. Therapeutic targets are now seeing the full force of modern organic chemistry.
Using simple concepts exploited by nature’s synthesis of naturally occurring
small molecules, small molecules with the physical properties required of drugs
yet with the topographic properties needed for achieving the impossible are now
accessible. Bravo!
Stuart L. Schreiber

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附件 1 : Diversity-Oriented_Synthesis,_Basics_and_Applications_in_Organic_Synthesis,_Drug_Discovery,_and_Chemical_Biology.pdf

2014-03-27 09:30:06, 20.72 M