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合成与植物化学结合的方向Diversity-Oriented Synthesis
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The gap between insights into human disease and therapeutics that arise from these insights is closing, but it cannot close fast enough. Society has patiently invested in science. But its expectation of scientists—that we mitigate suffering from disease— must be met if we expect to receive its support in the future. Advances in human biology are revealing novel insights into the cause of disease and requirements for the maintenance of disease. But the therapeutic targets that are arising, such as transcription factors and RNA molecules, do not fit conveniently into what we believe is currently achievable in drug discovery. Overcoming this belief is the twenty-first century challenge for organic chemistry, organic synthesis, and chemical biology. If we can do so, drug discovery and human health will be transformed. The insights provided in Diversity-Oriented Synthesis: Basics and Applications in Organic Synthesis, Drug Discovery, and Chemical Biology leave me feeling optimistic. I can sense the fearlessness and audacity of the authors as they undertake the impossible. The three-dimensional world of biological macromolecules is now interfaced with the three-dimensional world of small molecules to a far greater degree. Therapeutic targets are now seeing the full force of modern organic chemistry. Using simple concepts exploited by nature’s synthesis of naturally occurring small molecules, small molecules with the physical properties required of drugs yet with the topographic properties needed for achieving the impossible are now accessible. Bravo! Stuart L. Schreiber |
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2014-03-27 09:30:06, 20.72 M
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