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转角处的蜕变

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虫号: 1215703
注册: 2011-02-28
性别: GG
专业: 微生物药物

[求助] 编辑回稿了，求虫友们帮我看看接收的概率高吗？已有1人参与

The reviewer(s) would like to see some revisions made to your manuscript before the next re-evaluation step. Therefore, I invite you to respond to the reviewer(s)' comments and revise your manuscript. This second evaluation step does not necessary implicate that your manuscript will be finally accepted.
IMPORTANT: Your original files are available to you when you upload your revised manuscript. Please delete any redundant files before completing the submission.
Because we are trying to facilitate timely publication of manuscripts submitted to Drug Development and Industrial Pharmacy, your revised manuscript should be uploaded as soon as possible. If it is not possible for you to submit your revision in a reasonable
amount of time, we may have to consider your paper as a new submission.

Reviewer: 1

Comments to the Author
This article is mainly to investigate the spectral patterns in the Nifedipine/ Soluplus/ Kollidon solid dispersions (SD).The evaluation of the solid dispersions was also done. The authors have done many works in order to make the experiment persuasive and creditable. Some questions and advice were given about this article。
1. The X-ray diffraction method should be employed in comparison to FT-IR.
2.The aging of solid dispersions is a common problem。The application of different preparation methods was not enough to deal with the aging problem。 The formula modification attempts were absent in this article。
3.The publication period of most references was a little old and should be updated.

Peer Reviewer: 2

Comments to the Author

1. Please modify the English expressions in details of this paper carefully.
2. Are the samples prepared for SEM before or after milling? If they are milled samples, the SEM spectrum cannot tell the original morphology. And SEM may not be a strong technic to distinguish the polymorphs of the materials (amorphous or crystalline).
3. Could the author provide a Tg of the formulation from the DSC, which could be a better proof to prove the formulations are amorphous?
4. “The interaction strength between the drugs and the polymers can determine the degree that the crystal state change into the amorphous state.” Is there any paper support this theory?
5. If the author could show the SEM under the same enlargement factor , that would be easy to compare.
6. Could the author explain the Figure 7 more in details?
7. Is Figure 8 drawn based on the FT-IR results? Could the author please tell what FTIR in corresponded with which interactions?
8. Is the intensity of the FTIR related to the amount author used to make the KBr pellet? How to control this variable?
9. Is there any possible that there also exists interaction between two polymers in formulation?
And please explain why the author used both two polymers in one formulation?
求各位热心虫友帮我看看接收的概率高吗？这个修改意见算多吗？

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