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【答案】应助回帖
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dala1990: 金币+5, ★★★很有帮助, 您好，请问能不能再帮我看看检索号呢。谢谢了。 2014-03-03 10:27:00
oven1986: 检索EPI+1, 感谢应助，鼓励一下。 2014-03-03 23:09:20
入藏号: WOS:000328606500024
Asymmetric Synthesis of Oxa-spirocyclic Indanones with Structural Complexity via an Organocatalytic Michael-Henry-Acetalization Cascade
作者:Xie, X (Xie, Xin)[ 1 ] ; Peng, C (Peng, Cheng)[ 1,2 ] ; Leng, HJ (Leng, Hai-Jun)[ 2 ] ; Wang, B (Wang, Biao)[ 2 ] ; Tang, ZW (Tang, Zheng-Wei)[ 1 ] ; Huang, W (Huang, Wei)[ 1 ]
SYNLETT
卷: 25
期: 1
页: 143-147
DOI: 10.1055/s-0033-1340077
出版年: JAN 2 2014
查看期刊信息
摘要
The highly enantioselective preparation of drug-like oxa-spirocyclic indanone derivatives employing a multicomponent cascade reaction is described. This approach utilizes an organocatalytic Michael reaction followed by a Henry-acetalization sequence that yields the desired chiral spirocyclic backbone, bearing four contiguous stereogenic centers and multiple functional groups, in good yields and high stereoselectivities (up to 99% ee and 95:5 dr).
关键词
作者关键词 rganocatalysis; chiral indanone; oxa-spirocycles; tandem reactions; asymmetric synthesis
KeyWords Plus IPHENYLPROLINOL SILYL ETHER; RECEPTOR ANTAGONISTS; 4 STEREOCENTERS; EFFICIENT; ADDITIONS; NITROALKENES; DERIVATIVES; ACTIVATION; CATALYSIS; ALDEHYDES
作者信息
通讯作者地址: Peng, C (通讯作者)
Chengdu Univ Tradit Chinese Med, State Key Lab Breeding Base Systemat Res Dev & Ut, Chengdu 611137, Peoples R China.
地址:
[ 1 ] Chengdu Univ Tradit Chinese Med, State Key Lab Breeding Base Systemat Res Dev & Ut, Chengdu 611137, Peoples R China
[ 2 ] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Peoples R China
电子邮件地址:pengchengchengdu@126.com; huangwei@cdutcm.edu.cn
基金资助致谢
基金资助机构
授权号
Specialized Research Fund for the Doctoral Program of Higher Education
20125132120005
Application Foundation of the Science and Technology Department of Sichuan Province
2011JZY037
National Science Foundation of China
81303208
查看基金资助信息
出版商
GEORG THIEME VERLAG KG, RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
类别 / 分类
研究方向:Chemistry
Web of Science 类别:Chemistry, Organic
文献信息
文献类型:Article
语种:English
入藏号: WOS:000328606500024
ISSN: 0936-5214
电子 ISSN: 1437-2096
期刊信息
Impact Factor (影响因子): Journal Citation Reports®
其他信息
IDS 号: 274KZ
Web of Science 核心合集中的 "引用的参考文献": 37
Web of Science 核心合集中的 "被引频次": 0
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