±±¾©Ê¯ÓÍ»¯¹¤Ñ§Ôº2026ÄêÑо¿ÉúÕÐÉú½ÓÊÕµ÷¼Á¹«¸æ
²é¿´: 328  |  »Ø¸´: 4
¡¾½±Àø¡¿ ±¾Ìû±»ÆÀ¼Û4´Î£¬×÷ÕßyalefieldÔö¼Ó½ð±Ò 4 ¸ö
µ±Ç°Ö÷ÌâÒѾ­´æµµ¡£

[×ÊÔ´] The Trouble with QSAR

(or How I Learned To Stop Worrying and Embrace Fallacy)
Stephen R. Johnson*
Bristol-Myers Squibb, Co.,
J. Chem. Inf. Model. 2008, 48, 25-26

Abstract: A general feeling of disillusionment with QSAR has settled across the modeling community in recent years. Most practitioners seem to agree that QSAR has not fulfilled the expectations set for its ability to predict
biological activity. Among the possible reasons that have been proposed recently for this disappointment are chance correlation, rough response surfaces, incorrect functional forms, and overtraining. Undoubtedly, each of these plays an important role in the lack of predictivity seen in most QSAR models. Likely to be just as important is the role of the fallacy cum hoc ergo propter hoc in the poor prediction seen with many QSAR models. By embracing fallacy along with an over reliance on statistical inference, it may well be that the manner in which QSAR is practiced is more responsible for its lack of success than any other innate cause.
»Ø¸´´ËÂ¥
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

aydxhsg

½ð³æ (ÕýʽдÊÖ)


¡ï¡ï¡ï¡ï¡ï ÎåÐǼ¶,ÓÅÐãÍÆ¼ö

ºÃºÃºÃ
¶¥¶¥¶¥...........
2Â¥2008-01-29 10:11:20
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû
Ïà¹Ø°æ¿éÌø×ª ÎÒÒª¶©ÔÄÂ¥Ö÷ yalefield µÄÖ÷Ìâ¸üÐÂ
¡î ÎÞÐǼ¶ ¡ï Ò»ÐǼ¶ ¡ï¡ï¡ï ÈýÐǼ¶ ¡ï¡ï¡ï¡ï¡ï ÎåÐǼ¶
×î¾ßÈËÆøÈÈÌûÍÆ¼ö [²é¿´È«²¿] ×÷Õß »Ø/¿´ ×îºó·¢±í
[¿¼ÑÐ] 359Çóµ÷¼Á +4 hhhhaaaa$ 2026-04-04 4/200 2026-04-04 14:54 by zzchen2000
[¿¼ÑÐ] ²ÄÁϵ÷¼Á +3 ¸ï΢¹ð 2026-04-04 3/150 2026-04-04 14:53 by dongzh2009
[¿¼ÑÐ] 292Çóµ÷¼Á +9 2022080213 2026-04-04 11/550 2026-04-04 12:17 by 2022080213
[¿¼ÑÐ] 280Çóµ÷¼Á +21 ¹¾ààÏþÏþ 2026-04-02 22/1100 2026-04-04 11:12 by Öí»á·É
[¿¼ÑÐ] 081200-11408-276ѧ˶Çóµ÷¼Á +5 ´Þwj 2026-04-03 5/250 2026-04-03 15:06 by arrow8852
[¿¼ÑÐ] ¸´ÊÔµ÷¼Á +5 ´ºÈÕÀ´ÐÅ- 2026-04-03 5/250 2026-04-03 15:01 by buqi613
[¿¼ÑÐ] µ÷¼ÁÇóÖú +8 Ïë»»ÊÖ»ú²»Ïë½âÊ 2026-04-02 11/550 2026-04-03 14:16 by ÐÇ¿ÕÐÇÔÂ
[¿¼ÑÐ] 085600ר˶²ÄÁÏÓ뻯¹¤348·ÖÇóµ÷¼Á +10 ÉÏѧÀ²£¡ 2026-04-01 11/550 2026-04-03 14:13 by °ÙÁéͯ888
[¿¼ÑÐ] 0705Àíѧ294Çóµ÷¼Á +3 ³É¹û³É¹ûcg5 2026-04-03 3/150 2026-04-03 14:04 by simons1972
[¿¼ÑÐ] 321Çóµ÷¼Á +17 y-yh 2026-04-01 20/1000 2026-04-03 12:57 by y-yh
[¿¼ÑÐ] ר˶ 351 086100 Ò²ÊÇ¿¼µÄ²Ä¿Æ»ù ±¾¿ÆÒ²ÊDzÄÁÏ +8 202451007219 2026-04-02 8/400 2026-04-03 09:50 by À¶ÔÆË¼Óê
[¿¼ÑÐ] 326Çóµ÷¼Á +3 9ahye 2026-04-02 4/200 2026-04-03 08:43 by Jaylen.
[¿¼ÑÐ] ½»Í¨ÔËÊ俼ÊÔ264·ÖÇ󹤿Ƶ÷¼Á +4 jike777 2026-04-02 4/200 2026-04-02 21:53 by zllcz
[¿¼ÑÐ] 337Çóµ÷¼Á +11 ¡¶Ê÷¡· 2026-03-29 11/550 2026-04-02 10:20 by ²»³Ôô~µÄ؈
[¿¼ÑÐ] 085600£¬321·ÖÇóµ÷¼Á +13 ´ó²öС×Ó 2026-03-31 13/650 2026-04-01 12:35 by chemdavid
[¿¼ÑÐ] ±¾2Ò»Ö¾Ô¸C9-333·Ö£¬²ÄÁÏ¿ÆÑ§Ó빤³Ì£¬Çóµ÷¼Á +9 ÉýÉý²»½µ 2026-03-31 9/450 2026-03-31 18:01 by Î޼ʵIJÝÔ­
[¿¼ÑÐ] 254²ÄÁÏÓ뻯¹¤Çóµ÷¼Á +3 º²¶¬ÁÖéª 2026-03-30 4/200 2026-03-31 17:53 by yishunmin
[¿¼ÑÐ] 370Çóµ÷¼Á +3 080700µ÷¼Á 2026-03-30 3/150 2026-03-31 01:09 by A_Zhe
[¿¼ÑÐ] 279Çóµ÷¼Á +12 jµÄÁ¢·½ 2026-03-29 12/600 2026-03-30 20:30 by dick_runner
[¿¼ÑÐ] 086000ÉúÎïÓëÒ½Ò©µ÷¼Á +5 Feisty¡£ 2026-03-28 9/450 2026-03-29 12:02 by longlotian
ÐÅÏ¢Ìáʾ
ÇëÌî´¦ÀíÒâ¼û