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大分子的评审意见，帮忙看看什么意思，20金币答谢
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The authors rely heavily on 1HNMR characterization. For quantification this is not always appropriate. End groups are small and often shielded by larger resonances. PEO-TEMPO and PCL-TEMPO should therefore also be analyzed by MALDI MS In fig 6 and more particularly Fig 9, a clear shoulder and low molecular weight fraction are visible in the trace of the triblock copolymers. This raises doubts over the complete formation and purity of the triblock copolymer. Most appropriate would be to analyze the samples with 2D chromatography. Another option would be to treat the samples with scavenger resin (azide and alkyne functional Merrifield resin for removal of unreacted alkynes and azides.) What is the yield of the triblock copolymers after work up? The triblock coupling efficiency as is calculated should be reformulated to show the ratio between the different blocks. This gives much more valuable information, because it can show the efficiency of both coupling procedures. The calculation procedure can be shifted to the suppl. info. Why is the reaction performed at 90°C? This one pot procedure could in principle also be performed at lower temperatures, which would yield another benefit toward other procedures. This experiment is strongly recommended. If it has already been investigated, then a comment on temperature effects should be included. For the one-pot procedure one equivalent of CuBr is used, which is in principle fully used by ATRNC. This could lead to problems with the click chemistry coupling. The authors should comment about this (is click chemistry much faster than ATRNC?, have they investigated different ratios of CuBr?). |
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2楼2008-01-21 12:06:11
lovehappy2008
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liuxingyu(金币+4,VIP+0):2D chromatography 是什么测试呀？这个不懂呀
liuxingyu(金币+4,VIP+0):2D chromatography 是什么测试呀？这个不懂呀
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1 The authors rely heavily on 1HNMR characterization. For quantification this is not always appropriate. End groups are small and often shielded by larger resonances. 貌似是说你的测试结果仅靠1HNMR确定是远远不够的，还需作MALDI MS 和 2D chromatography 2 What is the yield of the triblock copolymers after work up? 需要计算一下产率 3Why is the reaction performed at 90°C? 有没有更加合适的反应条件 有没有试过 different ratios of CuBr 评审意见，应该是要你补一些数据 [ Last edited by lovehappy2008 on 2008-1-21 at 12:40 ] |
3楼2008-01-21 12:38:06
yfliu
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liuxingyu(金币+15,VIP+0):请教一下2D 色谱是什么测试呀？能不能详细说明说明呀？怎么做？
liuxingyu(金币+15,VIP+0):请教一下2D 色谱是什么测试呀？能不能详细说明说明呀？怎么做？
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The authors rely heavily on 1HNMR characterization. For quantification this is not always appropriate. End groups are small and often shielded by larger resonances. 作者过于依赖1HNMR表征。端基较小，常被大的共振信号所遮盖。 PEO-TEMPO and PCL-TEMPO should therefore also be analyzed by MALDI MS In fig 6 and more particularly Fig 9, a clear shoulder and low molecular weight fraction are visible in the trace of the triblock copolymers. This raises doubts over the complete formation and purity of the triblock copolymer. Most appropriate would be to analyze the samples with 2D chromatography. Another option would be to treat the samples with scavenger resin (azide and alkyne functional Merrifield resin for removal of unreacted alkynes and azides.) 图6中，PEO-TEMPO和PCL-TEMPO应该再用MALDI MS 分析。特别是图9，在痕量的三嵌段共聚物中有明显的肩峰和低分子量部分。这不禁使人怀疑三嵌段共聚物是否生成完全，其纯度如何。最好用2D 色谱进行分析。其他可选方法还有用大孔树脂处理样品（用叠氮炔型Merrifield功能树脂去除未反应的炔和叠氮化合物） What is the yield of the triblock copolymers after work up? 合成后三嵌段共聚物的产率如何？ The triblock coupling efficiency as is calculated should be reformulated to show the ratio between the different blocks. This gives much more valuable information, because it can show the efficiency of both coupling procedures. The calculation procedure can be shifted to the suppl. info. 计算的三嵌段耦合效率应该再用公式表示其与不同嵌段比的关系。这样可以反映两种耦合过程的效率，能提供更有价值的信息。计算过程可以置于附录中。 Why is the reaction performed at 90°C? This one pot procedure could in principle also be performed at lower temperatures, which would yield another benefit toward other procedures. This experiment is strongly recommended. If it has already been investigated, then a comment on temperature effects should be included. 反应温度为什么选定90°C？这种一锅法从原理上讲可以在较低的温度下进行，与其他过程比，可以有另一种优势。强烈推荐这样的实验。如果已经研究了，应该包括温度的影响。 For the one-pot procedure one equivalent of CuBr is used, which is in principle fully used by ATRNC. This could lead to problems with the click chemistry coupling. The authors should comment about this (is click chemistry much faster than ATRNC?, have they investigated different ratios of CuBr?). 一锅法中等量的CuBr，原理上讲会为ATRNC完全用完，这会产生“点击化学”耦合问题。作者应对此进行评价（点击化学是否比ATRNC更快？是否做了不同比例的CuBr？）。 |
4楼2008-01-21 21:05:43
lovehappy2008
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5楼2008-01-22 00:10:04
yfliu
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6楼2008-01-22 14:06:40
