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【答案】应助回帖
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bonny928: 金币+10, ★★★★★最佳答案, thanks~ 2014-02-09 21:39:04
jssxh: 金币+2, 检索EPI+1, 谢谢参与，请继续关注本版块！ 2014-02-10 09:49:02
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Accession number: 20140517244846
Title: Design, synthesis and characterization of 3-alkyl substituted chlorine derivatives
Authors: Cui, Bing Cun1, 2; Yu, Xin1; Ni, Dong Mei1; Lu, Yuan Dong1; Yoon, I.L.2; Shim, Young Key2
Author affiliation: 1 College of Medicine, Hubei Polytechnic University, Huangshi, China
2 PDT Research Institute, School of Nano System Engineering, Inje University, Gimhae, Korea, Republic of
Source title: Journal of Chemical and Pharmaceutical Research
Abbreviated source title: J. Chem. Pharm. Res.
Volume: 5
Issue: 12
Issue date: 2013
Publication year: 2013
Pages: 776-781
Language: English
E-ISSN: 09757384
Document type: Journal article (JA)
Publisher: Journal of Chemical and Pharmaceutical Research, 3/668 Malviya Nagar, Jaipur, Rajasthan, India
Abstract: The novel 3-alkyl substituted chlorin derivatives exhibiting good lipophilicity were obtained from methyl pheophorbide-a by modification of the peripheral functional groups. The vinyl group at 3-position was oxidized with OsO4 and NaIO4 to form the formyl group and the Grignard reaction of this aldehyde with the alkyl magnesium bromide was carried out to give the corresponding 3-(1-hydrroxylalkyl) pheophorbide-a. The 3-(1-hydrroxylalkyl) functional group was converted into 3-alkyl chain by dehydration and hydrogenation. The Qy band of prepared photosensitizers were affected by the substituent on the Qy axis (N21-N23). The structures of new photosensitizers were characterized by elemental analysis, UV-vis and 1H NMR spectra.
Number of references: 13
Main heading: Photosensitizers
Controlled terms: Complexation - Functional groups - Nuclear magnetic resonance spectroscopy - Photodynamic therapy - Synthesis (chemical)
Uncontrolled terms: Chlorins - Formyl group - Grignard reaction - H NMR spectra - Lipophilicity - Magnesium bromide - Methyl pheophorbide-a - Synthesis and characterizations
Classification code: 741.1 Light/Optics - 802.2 Chemical Reactions - 804.1 Organic Compounds - 932.2 Nuclear Physics
Database: Compendex
Compilation and indexing terms, © 2013 Elsevier Inc.
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