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liyan20220: ½ð±Ò+5, ·ÒëEPI+1 2014-01-14 18:17:56
liyan20220: ½ð±Ò+5, ·ÒëEPI+1 2014-01-14 18:17:56
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Antimicrobial peptides are antimicrobial peptides with molecular weight of about 1000-7000 and consists of 12-50 amino acids whose antibacterial spectrum include Gram-positive bacteria, Gram-negative bacteria and fungi. ORBK antimicrobial peptides are cationic peptides derived from Odorrcma grahami skin secretions containing 16 amino acid residues. A cyclic peptide, ORBK antimicrobial peptides have not only antimicrobial activity , but also a stable insulinotropic activity. Currently ORBK antimicrobial peptide can only be extracted and synthesized . The much smaller yields of Odorrcma grahami skin secretions extraction is a critical technical bottleneck and the cost of chemical synthesis is high because it requires a cyclic process . In this paper, we use a genetic engineering combined H2O2 oxidation method, successfully obtained ORBK antimicrobial peptides .The mechanism of antimicrobial peptides has been explored and bacteria binding peptides D29P63 and PK34 were studied also . ÎÞÖ¸Å̳ôÍÞOdorrcma grahami ÇëºË¶Ô¡£ |

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