| 查看: 1892 | 回复: 3 | |||
| 本帖产生 1 个 PhEPI ，点击这里进行查看 | |||
[求助]
求助absorption window， pre-systemic metabolism， membrane permeability 已有1人参与
|
|||
|
本人小菜鸟一只，研究僧方向是“中药药代动力学” 在《色谱B》杂志《Comparative pharmacokinetics of timosaponin B-II and timosaponin A-III after oral administration of Zhimu–Baihe herb-pair, Zhimu extract, free timosaponin B-II and free timosaponin A-III to rats》一文中看到这么一段话  是专门分析药物进入体内后的药时曲线出现双峰现象的  有几个学术名词“absorption window”， “pre-systemic metabolism”， “membrane permeability”不太懂啥意思  还请各位大神多多指教  下面是文章中的那段话 It is of interest to note that double plasma concentration peaks of TB-II were observed after oral administration of ZME and free TBII. This phenomenon was similar to that in other reports. It is well known that drug absorption is a very complex process that manifests itself through potential interaction with a host of physicochemical and physiological variables. Some factors that may affect the absorption process include membrane permeability, pre-systemic metabolism, “absorption window” along the gastrointestinal tract, enterohepatic recirculation, variable gastric emptying and drug-drug interactions. Therefore, atypical drug absorption profiles such as double-peak and absorption window-type absorption profiles are often encountered. Further identification of enterohepatic recirculation may be required by a comparison of AUC obtained after oral administration of the compound in normal and bile duct cannulated rats. Notably, the concentration-time curve of TB-II after oral administration of ZMBHHP displayed distinct triple peaks. This phenomenon was revealed here for the first time for timosaponin. The factors mentioned above may also contribute to this result; besides another probable factor is distribution re-absorption. Since Baihe is present in ZMBHHP, the concentration of TB-II in tissue may be accordingly much higher than that in plasma. It is possible for TB-II to transfer from tissue toplasma, causing another peak in plasma. |
回复此楼» 猜你喜欢
有多少人是今天查系统知道结果的？
已经有19人回复
-
面上合作单位盖章
已经有9人回复
-
面上函评意见出来了，像什么等级？
已经有17人回复
-
为什么国自然不能直接公布
已经有5人回复
-
梦想
已经有7人回复
-
学科评审组评审是指会评吗？
已经有4人回复
-
为什么资助数各大高校都创新高，自己申请怎么就这么难
已经有14人回复
-
小白求助 投论文要求的highlights应该如何写
已经有4人回复
-
麻烦专家们看看评委们的意见（F口面上）
已经有12人回复
-
怎么看青基中了没有啊
已经有6人回复
辣笔v小新
荣誉版主 (职业作家)
- PhEPI: 4
- 应助: 199 (高中生)
- 贵宾: 1.262
- 金币: 22485.6
- 散金: 210
- 红花: 115
- 沙发: 34
- 帖子: 4052
- 在线: 1192.8小时
- 虫号: 2215793
- 注册: 2012-12-31
- 专业: 化学生物学与生物有机化学
- 管辖: 药学
2楼2014-04-06 12:40:31
3楼2018-03-13 11:00:53
4楼2018-03-14 07:35:57
20
