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金虫 (小有名气)

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专业: 生物技术药物

[求助] 求助absorption window， pre-systemic metabolism， membrane permeability 已有1人参与

本人小菜鸟一只，研究僧方向是“中药药代动力学”

在《色谱B》杂志《Comparative pharmacokinetics of timosaponin B-II and timosaponin
A-III after oral administration of Zhimu–Baihe herb-pair, Zhimu extract, free timosaponin B-II and free timosaponin A-III to rats》一文中看到这么一段话

是专门分析药物进入体内后的药时曲线出现双峰现象的

有几个学术名词“absorption window”， “pre-systemic metabolism”， “membrane permeability”不太懂啥意思

还请各位大神多多指教

下面是文章中的那段话

It is of interest to note that double plasma concentration peaks of TB-II were observed after oral administration of ZME and free TBII. This phenomenon was similar to that in other reports. It is well known that drug absorption is a very complex process that manifests itself through potential interaction with a host of physicochemical and physiological variables. Some factors that may affect the absorption process include membrane permeability, pre-systemic metabolism, “absorption window” along the gastrointestinal tract, enterohepatic recirculation, variable gastric emptying and drug-drug interactions. Therefore, atypical drug absorption profiles such as double-peak and absorption window-type absorption profiles are often encountered. Further identification of enterohepatic recirculation may be required by a comparison of AUC obtained after oral administration of the compound in normal and bile duct cannulated rats. Notably, the concentration-time curve of TB-II after oral administration of ZMBHHP displayed distinct triple peaks. This phenomenon was revealed here for the first time for timosaponin. The factors mentioned above may also contribute to this result; besides another probable factor is distribution re-absorption. Since Baihe is present in ZMBHHP, the concentration of TB-II in tissue may be accordingly much higher than that in plasma. It is possible for TB-II to transfer from tissue toplasma, causing another peak in plasma.

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