| 查看: 1747 | 回复: 3 | ||
| 本帖产生 1 个 PhEPI ，点击这里进行查看 | ||
[求助]
求助absorption window， pre-systemic metabolism， membrane permeability 已有1人参与
|
||
|
本人小菜鸟一只，研究僧方向是“中药药代动力学” 在《色谱B》杂志《Comparative pharmacokinetics of timosaponin B-II and timosaponin A-III after oral administration of Zhimu–Baihe herb-pair, Zhimu extract, free timosaponin B-II and free timosaponin A-III to rats》一文中看到这么一段话  是专门分析药物进入体内后的药时曲线出现双峰现象的  有几个学术名词“absorption window”， “pre-systemic metabolism”， “membrane permeability”不太懂啥意思  还请各位大神多多指教  下面是文章中的那段话 It is of interest to note that double plasma concentration peaks of TB-II were observed after oral administration of ZME and free TBII. This phenomenon was similar to that in other reports. It is well known that drug absorption is a very complex process that manifests itself through potential interaction with a host of physicochemical and physiological variables. Some factors that may affect the absorption process include membrane permeability, pre-systemic metabolism, “absorption window” along the gastrointestinal tract, enterohepatic recirculation, variable gastric emptying and drug-drug interactions. Therefore, atypical drug absorption profiles such as double-peak and absorption window-type absorption profiles are often encountered. Further identification of enterohepatic recirculation may be required by a comparison of AUC obtained after oral administration of the compound in normal and bile duct cannulated rats. Notably, the concentration-time curve of TB-II after oral administration of ZMBHHP displayed distinct triple peaks. This phenomenon was revealed here for the first time for timosaponin. The factors mentioned above may also contribute to this result; besides another probable factor is distribution re-absorption. Since Baihe is present in ZMBHHP, the concentration of TB-II in tissue may be accordingly much higher than that in plasma. It is possible for TB-II to transfer from tissue toplasma, causing another peak in plasma. |
回复此楼» 猜你喜欢
071000生物学调剂
已经有3人回复
-
085600材料与化工301分求调剂院校
已经有5人回复
-
081700，311，求调剂
已经有15人回复
-
一志愿北京化工085600 310分求调剂
已经有18人回复
-
材料与化工371求调剂
已经有14人回复
-
336材料与化工085600求调剂
已经有7人回复
-
材料334求调剂
已经有18人回复
-
331求调剂
已经有8人回复
-
332求调剂
已经有17人回复
-
一志愿南京航空航天大学 材料与化工329分求调剂
已经有4人回复
辣笔v小新
荣誉版主 (职业作家)
- PhEPI: 4
- 应助: 199 (高中生)
- 贵宾: 1.262
- 金币: 22484.8
- 散金: 210
- 红花: 115
- 沙发: 34
- 帖子: 4052
- 在线: 1192.8小时
- 虫号: 2215793
- 注册: 2012-12-31
- 专业: 化学生物学与生物有机化学
- 管辖: 药学
2楼2014-04-06 12:40:31
羌管弄晴
新虫 (著名写手)
- 应助: 0 (幼儿园)
- 金币: 1179.2
- 散金: 1152
- 红花: 14
- 沙发: 6
- 帖子: 1378
- 在线: 108.6小时
- 虫号: 5441979
- 注册: 2017-01-04
- 性别: GG
- 专业: 光学
3楼2018-03-13 11:00:53
4楼2018-03-14 07:35:57
