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DRUG DISCOVERY from Bedside to Wall Street
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DRUG DISCOVERY from Bedside to Wall Street Tamas Bartfai, Ph.D. & Graham V. Lees, Ph.D. 1. THE ART OF PUTTINGA MOLECULE INTO MAN 3 2. RAISING AND RISING EXPECTATIONS 13 3. HISTORY IS GOOD TO KNOW 23 4. THE BETTERBETA-BLOCKER BARRIER 5. WHY SOME GOOD DRUGS DO NOT GET A CHANCE AND WHY OTHERS FAIL 6. ABOUT THE ECONOMICS OF TARGET AND CLINICAL CANDIDATE SELECTION 7. TARGET-BASED DRUG DISCOVERY: PARTI 8. CHANGES NEED TO BE MADE 9. TARGET-BASED DRUG DISCOVERY: PART II 10. “DRUGABLE” TARGETS 11. SO MANY DRUGS, S O FEW ENTITIES 12. HOW TO FIND A CANDIDATE DRUG 13. PRACTICALITIES: THE HOOPS AND HURDLES OF BIG PHARMA 14. PRACTICAL TRIALS FOR A BALANCED PORTFOLIO 141 15. HOW TO IMPROVE THE ODDS OF FINDING A SAFE DRUG THAT WORKS 145 16. THE TRIBULATIONS OF CLINICAL TRIALS 17. LINKING PUTATIVE TARGETS TO DISEASE STATES 18. MORE WAYS TO LOOK FOR TARGETS 19. THE BUSINESS BASICS (GENERAL) 20. ADDING VALUE IN A GROWTH INDUSTRY 21. WHAT’S THEMOST PROFITABLE APPROACH? 22. PHARMACOECONOMICS FOR BIOTECH 23. SHRINKINGVALUE OF TARGETS 24. ASSESSING COMPANY ASSETS? LOOK IN THE LIBRARY 25. TO MERGE OR NOT TO MERGE? 26. WORKING WITH THE FOOD AND DRUG ADMINISTRATION (FDA) 27. REGULATING REGULATORY REGIMENS RELIABLY 28. THE HYPOTHESIS IS: THERE IS A BETTERWAY 29. WHAT ARE “WE” ALL WORKING ON? 30. MORE TABLETS TAKEN PER DAY THAN MEALS SERVED: |
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2014-01-02 15:06:42, 2.66 M
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