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[交流] HPLC METHODS FOR RECENTLY APPROVED PHARMACEUTICALS

HPLC METHODS FOR RECENTLY APPROVED PHARMACEUTICALS.png

PREFACE
This book is a collection of procedures for the analysis of more than 390 pharma-
ceuticals using high-performance liquid chromatography (HPLC) and covers the
literature up to the end of 2003. The current volume is a continuation of HPLC
Methods for Pharmaceutical Analysis, published in four volumes from 1997 to 2000.
The previous volumes described methods published in the literature through the
middle of 1998.
The current work lists procedures for the analysis of drugs in three broad categories:
ž Drugs that have been approved since the previous volumes were published.
ž Drugs that were approved when the previous volumes were published but for
which analytical methods were not then available in the literature.
ž Drugs for which procedures allowing determination in a blood matrix have only
become available since the previous volumes were published.
Please note that mention of a drug does not necessarily mean that it is currently
approved for use in the United States or indeed in any country.
Despite the ready availability of computer-aided literature, searching this resource
is not exploited as much as it might be. One reason for this reluctance is, of course,
that a computer search merely produces a listing of possibly relevant references.
Tedious and time-consuming searches in the library are necessary to ﬁnd the most
relevant reference that can be turned into a practical analytical procedure in the
searcher’s own laboratory. The reference ﬁnally chosen will, naturally, depend on
the individual circumstances, such as the matrix in which the drug is present,
availability of equipment, and so on. This book circumvents this lengthy process by
providing a number of abstracted and evaluated procedures for the analysis of each
drug. The analyst can rapidly identify a relevant procedure and put it into practice.
In addition to the analytical matrix, other factors may be important when choosing
an analytical procedure. Accordingly, we have noted such features of the analytical
procedures as sensitivity, mode of detection, other compounds that interfere with
the analysis, other drugs that may be determined at the same time, and so on.
Readers familiar with our previous publications, HPLC Methods for Pharmaceu-
tical Analysis, Volumes 1–4 (George Lunn and Norman R. Schmuff, John Wiley,
New York, 1997–2000) and Handbook of Derivatization Reactions for HPLC (George
Lunn and Louise C. Hellwig, John Wiley, New York, 1998), will notice many similar-
ities. The abstract structure is very similar, and the philosophy that the procedures
should be reproducible without reference to the original literature is unchanged.
A new feature is that the retention times (in minutes) of other drugs that may be
determined using the same system have been added in parentheses after the drug
name. Other data, such as the limit of detection (LOD), may also be added. The
retention time is the number without units. Unlike the previous volumes, this book
is not available on a CD in an electronic form.
At the end of the book a Cumulative Index and a Cross-Index to Other Substances
are provided. The Cumulative Index provides a comprehensive listing of the drugs
covered in this book and the previous volumes. The Cross-Index lists the other
compounds that may also be chromatographed under the conditions described in
the monographs in this book. Using the information in the monographs it may be
possible to develop chromatographic procedures for these compounds.
G EORGE L

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附件 1 : HPLC_METHODS_FOR_RECENTLY_APPROVED_PHARMACEUTICALS.pdf

2014-01-02 10:35:42, 3.6 M