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请哪位网友帮忙查一下下列1篇会议论文有没有被SCI收录，谢谢！ Spectroscopic Studies on the Interaction of Hemin with Human Telomeric G-Quadruplex DNA XU-JIAN LUO; QI-PIN QIN; KE-BIN HUANG; YAN-CHENG LIU; HONG LIANG Asian J. Chem., 2013, 25(11), pp 6396-6400 |
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baiyuefei
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2楼2013-12-20 16:34:53
baiyuefei
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Spectroscopic Studies on the Interaction of Hemin with Human Telomeric G-Quadruplex DNA 作者: Luo, XJ (Luo, Xu-Jian)[ 1,2 ] ; Qin, QP (Qin, Qi-Pin)[ 2 ] ; Huang, KB (Huang, Ke-Bin)[ 2 ] ; Liu, YC (Liu, Yan-Cheng)[ 2 ] ; Liang, H (Liang, Hong)[ 1,2 ] 来源出版物: ASIAN JOURNAL OF CHEMISTRY 卷:25 期:11 页:6396-6400 子辑:A 出版年:SEP 2013 被引频次: 0 (来自 Web of Science) 引用的参考文献: 20 [ 查看 Related Records ] 引证关系图 摘要: The interaction behaviours of hemin as a ligand binding with three types of human telomeric G-quadruplex DNA were examined by UV-visible and circular dichroism spectroscopic methods. The circular dichroism spectra of these three types of G-quadruplex DNA all showed major positive absorption peaks at ca. 290 nm with shoulder peaks at ca. 270 nm, along with a negative absorption peak at ca. 250 nm. The presence of hemin did not induce obvious circular dichroism spectral changes of these G-quadruplex DNA, which indicates that hemin is able to stabilize human telomeric antiparallel G-quadruplex DNA structure. For comparison, the addition of hemin induced obvious increment on the characteristic antiparallel circular dichroism absorption of the corresponding single-chain human telomeric sequences, which suggests that hemin may induce and stabilize the formation of antiparallel G-quadruplex DNA even in the absence of K+. On the other hand, the addition of the three types of G-quadruplex DNA into the hemin solution with gradually increasing concentrations induced significant hypochromicity (31.86-47.26 %) along with 11-23 nm of bathochromicity on the UV-visible absorption of hemin. From this result, it is suggested that the high binding affinity of hemin to antiparallel G-quadruplex DNA is based on the intensive intercalative binding mode of hemin to antiparallel G-quadruplex DNA by the pi-pi stacking between the macrocyclic aromatic hemin and the guanine quartet. 入藏号:WOS:000325089600119 文献类型: Article 语种: English 作者关键词: G-quadruplex DNA; Hemin; Telomeric DNA; Intercalative binding KeyWords Plus: INHIBITOR; COMPLEXES; SEQUENCE; BINDING; LIGAND 通讯作者地址: Liu, YC (通讯作者) Guangxi Normal Univ, State Key Lab Cultivat Base Chem & Mol Engn Med R, Sch Chem & Chem Engn, Guilin 541004, Peoples R China. 地址: |
3楼2013-12-20 16:35:07
baiyuefei
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4楼2013-12-20 16:35:23
