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e1m1a1i1l1金虫 (正式写手)
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Folic acid-functionalized magnetic ZnFe2O4 hollow microsphere core/mesoporous silica shell composite particles: Synthesis and application in drug release Materials Science and Engineering C 2013, 33: 2879-2884 |
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标题: Folic acid-functionalized magnetic ZnFe2O4 hollow microsphere core/mesoporous silica shell composite particles: Synthesis and application in drug release 作者: Yang, Dandan; Wei, Kaiwei; Liu, Qi; 等. 来源出版物: MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 卷: 33 期: 5 页: 2879-2884 DOI: 10.1016/j.msec.2013.03.006 出版年: JUL 1 2013 被引频次: 1 (来自所有数据库) |

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Folic acid-functionalized magnetic ZnFe2O4 hollow microsphere core/mesoporous silica shell composite particles: Synthesis and application in drug release 作者: Yang, DD (Yang, Dandan)[ 1,2 ] ; Wei, KW (Wei, Kaiwei)[ 1,2 ] ; Liu, Q (Liu, Qi)[ 1,2 ] ; Yang, Y (Yang, Yong)[ 1,2 ] ; Guo, X (Guo, Xue)[ 1,2 ] ; Rong, HR (Rong, Hongren)[ 1,2 ] ; Cheng, ML (Cheng, Mei-Ling)[ 1,2 ] ; Wang, GX (Wang, Guoxiu)[ 3 ] 来源出版物: MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 卷: 33 期: 5 页: 2879-2884 DOI: 10.1016/j.msec.2013.03.006 出版年: JUL 1 2013 被引频次: 1 (来自 Web of Science) 引用的参考文献: 34 [ 查看 Related Records ] 引证关系图 摘要: A drug delivery system was designed by deliberately combining the useful functions into one entity, which was composed of magnetic ZnFe2O4 hollow microsphere as the core, and mesoporous silica with folic acid molecules as the outer shell. Amine groups coated magnetic ZnFe2O4 hollow microsphere core/mesoporous silica shell (MZHM-MSS-NH2) composite particles were first synthesized by a one-pot direct co-condensation method. Subsequently a novel kind of folic acid-functionalized magnetic ZnFe2O4 hollow microsphere core/mesoporous silica shell (MZHM-MSS-NHFA) composite particles were synthesized by conjugating folic acid as targeted molecule to MZHM-MSS-NH2. Ibuprofen, a well-known antiphlogistic drug, was used as a model drug to assess the loading and releasing behavior of the composite microspheres. The results show that the MZHM-MSS-NHFA system has the higher capacity of drug storage and good sustained drug-release property. (C) 2013 Elsevier B.V. All rights reserved. 入藏号: WOS:000319630100053 文献类型: Article 语种: English 作者关键词: Magnetic particles; Mesoporous silica; Drug delivery; Folic acid KeyWords Plus: DELIVERY; MCM-41; SPHERES; NANOPARTICLES; EXCHANGE; SYSTEM 通讯作者地址: Liu, Q (通讯作者) Changzhou Univ, Sch Petrochem Engn, Changzhou 213164, Jiangsu, Peoples R China. 地址: [ 1 ] Changzhou Univ, Sch Petrochem Engn, Changzhou 213164, Jiangsu, Peoples R China [ 2 ] Changzhou Univ, Key Lab Fine Petrochem Technol, Changzhou 213164, Jiangsu, Peoples R China [ 3 ] Univ Technol Sydney, Sch Chem & Forens Sci, Ctr Clean Energy Technol, Sydney, NSW 2007, Australia 增强组织信息的名称 University of Technology Sydney 电子邮件地址: liuqi62@163.com 基金资助致谢: 基金资助机构 授权号 National Natural Science Foundation of China 20671045 20971060 International Science and Technology Cooperation Project of Changzhou city CZ20110023 Priority Academic Program Development of Jiangsu Higher Education Institutions [显示基金资助信息][隐藏基金资助信息] We thank the National Natural Science Foundation of China (No. 20671045, 20971060), the International Science and Technology Cooperation Project of Changzhou city (CZ20110023) and the project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions for financial support. 出版商: ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS Web of Science 类别: Materials Science, Biomaterials 研究方向: Materials Science IDS 号: 153VH ISSN: 0928-4931 |
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