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rio24金虫 (小有名气)
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10个金币求助－－阿司匹林引起胃肠道出血的原因
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一道考题，分值比较大 长期服用阿司匹林有时会引起胃肠道出血，为什么？ 希望有大侠能详细解答，谢谢 |
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karl2100(金币+1,VIP+0):多谢提供！
rio24(金币+5,VIP+0):谢谢解答～！
karl2100(金币+1,VIP+0):多谢提供！
rio24(金币+5,VIP+0):谢谢解答～！
| 阿司匹林是一个解热镇痛抗炎药,其作用机制是抑制体内前列腺素（PG）合成，PG是体内生物活性很强、很广的物质。其中PGE2具有致热、致炎、致痛、保护胃黏膜等作用。PGE2能防止有害因子损伤胃粘膜，能预防化学刺激引起的胃粘膜出血、糜烂与坏死，发挥细胞或粘膜保护作用。长期使用阿司匹林，由于抑制了前列腺素合成酶（COX—1），干扰PGS(主要为PGE2)合成，使PGE2生成减少，胃黏膜的屏障作用减弱，刺激胃粘膜，引起上腹部不适，胃灼痛，甚至诱发或加重溃疡和出血。 |
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karl2100(金币+1,VIP+0):多谢提供！
karl2100(金币+1,VIP+0):多谢提供！
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建议看看下面这本书吧。 Aspirin_and_Related_Drugs Contents 2 THE INDUSTRIAL HISTORY OF ANALGESICS: THE EVOLUTION OF ANALGESICS AND ANTIPYRETICS J.R. McTavish Recognition of Pain Therapeutic Nihilism and Fevers The Organic Chemical Industry The Salicylates The Value of a Good Name Conclusion References 4 PHARMACOKINETICS AND METABOLISM OF THE SALICYLATES G.G. Graham, M.S. Roberts, R.O. Day and K.D. Rainsford Introduction Absorption of Aspirin and Salicylate Distribution of Aspirin and Salicylate Elimination of Aspirin Elimination of Salicylate Metabolic Pathways of Salicylate Factors Controlling the Elimination of Aspirin and Salicylate Kinetics of Elimination of Salicylate Pro-Drugs Analytical Methods for the Salicylates Salicylate Derivatives Diflunisal Salicylamide References 5 METABOLISM AND PHARMACOKINETICS OF IBUPROFEN G.G. Graham and K.M. Williams Introduction Absorption Distribution Elimination Half-life and Clearance Factors Affecting the Elimination of Ibuprofen Pharmacokinetics, Plasma Concentrations and Clinical Response Analytical Methods References 6 PHARMACOKINETICS AND METABOLISM OF PARACETAMOL (ACETAMINOPHEN) G.G. Graham and M. Hicks Introduction Absorption Distribution © 2004 K.D. Rainsford Elimination Half-life and Clearance Factors Affecting the Elimination of Paracetamol Metabolism of Pro-drugs Analytical Methods References 7 PHARMACOLOGY AND BIOCHEMISTRY OF SALICYLATES AND RELATED DRUGS K.D. Rainsford Introduction Anti-inflammatory Effects Biochemical Effects of Salicylates in Relation to their Anti-inflammatory Actions Analgesic Activity Antipyresis References Appendix to Chapter 7 8 SIDE EFFECTS AND TOXICOLOGY OF THE SALICYLATES K.D. Rainsford Introduction Occurrence of Adverse Events from NSAIDs, including Aspirin Gastrointestinal Side Effects Hepatotoxicity Nephropathy Hypersensitivity Reactions and Asthma Teratogenesis and Pregnancy Miscellaneous Side Effects Acute Salicylate Poisoning Conclusions References 9 REYE’S SYNDROME AND ASPIRIN J.F.T. Glasgow and S.M. Hall Introduction Background Definition Clinical Features Investigations © 2004 K.D. Rainsford Differential Diagnosis Aetiology and Pathogenesis Management Principles The Future Conclusion Acknowledgements References 10 SALICYLATES IN THE TREATMENT OF ACUTE PAIN K.D. Rainsford Introduction Concepts of the Mode of Action in Acute Pain Early Observations in Various Pain States Efficacy in Various Pain Conditions Comparative Effects in Acute Pain States References 11 ACETYLSALICYLIC ACID FOR THE PREVENTION AND TREATMENT OF THROMBOEMBOLIC DISEASES K.E. Webert and J.G. Kelton The Role of Platelets in Haemostasis and Thrombosis The Role of Platelets in Acute and Chronic Vascular Injury Effects of Acetylsalicylic Acid on Platelet Function Pharmacokinetics of ASA Dose–Effect Relationships of ASA The Effects of ASA on Coagulation Factors, other than Platelets ASA for the Prevention of Vascular Thromboembolic Disease: Epidemiological Studies ASA for the Treatment of Acute Vascular Thromboembolic Events Novel Analogues of Salicylates and Further Developments References 12 USE OF SALICYLATES IN RHEUMATIC AND RELATED CONDITIONS W.W. Buchanan, W.F. Kean and K.D. Rainsford Introduction History Rheumatoid Arthritis Osteoarthritis Miscellaneous musculoskeletal disorders Drug Kinetics and Monitoring © 2004 K.D. Rainsford Adverse Events in Rheumatic Patients Factors Affecting Side Effects and Therapeutic Effects Toxicity Conclusions References . 13 ASPIRIN AND NSAIDs IN THE PREVENTION OF CANCER, ALZHEIMER’S DISEASE AND OTHER NOVEL THERAPEUTIC ACTIONS K.D. Rainsford Introduction Prevention of Colorectal and Other Cancers Alzheimer’s Disease and Related Dementias Copper Salicylates in the Treatment of Inflammatory Diseases and Cancer Therapeutic Uses of Aspirin in Pregnancy Kawasaki Disease Perturbed Metabolic States Immunological Effects Other Possible Uses Miscellaneous References 附件传不上来！ http://rapidshare.de/files/18302639/Aspirin.rar.html http://rapidshare.com/files/1138 ... Drugs-KINGDWARF.zip [ Last edited by fxzxp on 2008-1-23 at 10:08 ] |
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