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[求助]
医学类摘要翻译，谢谢
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Background: Cisatracurium in clinical practice is devoid of histamine-induced cardiovascular effects. On the other hand, 2 ED95 doses of cisatracurium (100 μ g/kg) do not create satisfactory intubating conditions such as those seen with equipotent doses of atracurium. The recommended intubating dose of cisatracurium is 3 ED95. To understand this discrepancy better, we evaluated the potency and onset of atracurium and cisatracurium. Materials and Methods: The study designed as randomized controlled clinical trial to compare between atracurium (2×ED95) and different doses of cisatracurium (2×ED95, 4×ED95, 6×ED95) regarding onset time, duration of action, condition of intubation, hemodynamic effects, and sings of histamine release clinically. Sixty four patients were randomly assigned to one of four groups, the first group (group 1) received 2×ED95 dose of atracurium, group 2 received 2×ED95 dose of cisatracurium, group 3 received 4×ED95 dose of cisatracurium, while group 4 received 6×ED95 dose of cisatracurium. The Datex relaxograph (Type NMT-100-23-01, S/N: 37541) for neuromuscular monitoring was used. Results: HR, MABP was statistically significant increased post-intubation with administration of 2×ED95 dose of atracurium in group 1 and the same dose of cisatracurium in group 2 but 5-20 min later was not statistically significant with administration of 4×ED95 and 6×ED95 doses of cisatracurium in groups 3 and 4, respectively. Onset time was found to be significantly lower with 2×ED95 dose of atracurium than with the same dose of cisatracurium. At the same time, higher doses of cisatracurium (4×ED95 and 6×ED95) showed onset time and longer duration of action that was significantly lower than with atracurium and with lower dose of cisatracurium (2×ED95). Only 6×ED95 dose of cisatracurium showed statistically significant difference versus the atracurium dose with higher percentages of patients with excellent condition of intubation. 4×ED95 and 6×ED95 doses of cisatracurium were significantly better than 2×ED95 dose of cisatracurium. 2×ED95dose of atracurium and 2×ED95 dose of cisatracurium were similar, while 4×ED95 and 6×ED95 doses of cisatracurium were significantly better than atracurium and 2×ED95 dose of cisatracurium. Conclusion: The same dose (2×ED95 dose) atracurium is more effective neuromuscular blocking agent than cisatracurium, while higher doses of cisatracurium 4×ED95 and 6×ED95 provide more effective, more rapid neuromuscular blocking with longer duration of action, stable hemodynamic status, and no associated signs of histamine release clinically. |
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霜叶: 金币+40, 翻译EPI+1, ★★★很有帮助, 谢谢 2013-12-02 15:53:54
霜叶: 金币+40, 翻译EPI+1, ★★★很有帮助, 谢谢 2013-12-02 15:53:54
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背景： 在临床实践中顺式-阿屈库铵不产生组胺诱导的心血管效应。另一方面，2 ED95（95%的有效药物剂量）剂量顺式-阿屈库铵（100μg / kg以下）不会与等效剂量阿曲库铵一样产生满意的插管条件。 顺式-阿屈库铵的推荐插管剂量为3 ED95。为了理解这种差异更好，我们评价阿曲库铵和顺式-阿屈库铵的效力和起效时间。 材料和方法： 随机对照临床试验，比较阿曲库铵（2×ED95）和不同剂量顺式-阿屈库铵（2×ED95，4×ED95，6×ED95）就起效时间，作用时间，插管的状况，血流动力学影响的研究，和有无胺释放的临床迹象。64个病人被随机分成四组，第一组（第1组）接受2×ED95剂量阿曲库铵，2组接受2×ED95剂量顺式-阿屈库铵，第3组4×ED95剂量顺式-阿屈库铵，而第4组接收6×ED95顺式-阿屈库铵剂量。该德恩relaxograph（类型NMT-100-23-01，S / N：37541）用于监测神经肌肉。 结果： 插管给药2×ED95剂量阿曲库铵的第1组和第2组相同剂量顺式-阿屈库铵HR、平均动脉压有统计学显著意义（增加）；但5-20分钟后，分别与4×ED95组的第3组和6×ED95的第4组无统计学显著性。发病时间2×ED95剂量阿曲库铵相显著低于同剂量的顺式-阿屈库铵。与此同时，更高的剂量顺式-阿屈库铵（4×ED95和6×ED95）的显示发病时间和较长的作用时间比用阿曲库铵显和低剂量顺式-阿屈库铵（2×ED95）短。患者的插管条件优越比例较高的阿曲库铵的剂量只有6×ED95顺式-阿屈库铵的剂量与其有统计显著性差异。4×ED95和6×ED95剂量顺式-阿屈库铵都显著大于2×ED95剂量顺式-阿屈库铵。 2×ED95剂量阿曲库铵和2×ED95剂量顺式-阿屈库铵相似，而4×ED95和6×ED95剂量顺式-阿屈库铵的比阿曲库铵和2×ED95剂量顺式-阿屈库铵更好。 结论： 与顺式-阿屈库铵相比，相同的剂量（2×ED95剂量）阿曲库铵是更为有效的神经肌肉阻断剂，而较高剂量顺式-阿屈库铵4×ED95和6×ED95提供更有效、更快速的神经肌肉阻滞，持续时间长，稳定的血液动力学状态，没有有关的组胺释放的临床迹象。 |
2楼2013-11-27 19:57:08