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[求助]
QSAR建模文章修回,问题该如何回答?
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| How were the relative contributions of the steric, electrostatic, hydrophobic, H-bond donor and H-bond acceptor parameters (10.2, 25.6, 19.9, 30.7, and 13.6%, respectively) established? Given that the number of H-bond acceptors and donors varies with the specific substituents, how can these be pre-fixed? Likewise, how does the model accommodate differences in hydrophobicity or electronic characteristics? 改如何回答呢? |
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