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[求助]
求助论文检索号，谢谢大侠！
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| Bai-Jun Ye, Xue-Kun Liu, Sheng-Ming Jiang, Xun Cui*, and Hu-Ri Piao*. Synthesis of 2-(4-Substitutedbenzyl-[1,4]diazepan-1-yl)-N-(1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides as Inotropic Agents. |
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baiyuefei
版主 (文学泰斗)
风雪
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【答案】应助回帖
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gruyclewee: 金币+3, 感谢应助，奖励一下。 2013-11-19 09:14:44
gruyclewee: 金币+3, 感谢应助，奖励一下。 2013-11-19 09:14:44
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Synthesis of 2-(4-Substitutedbenzyl-[1,4]Diazepan-1-yl)-N-(1-Methyl-4,5-Dihydro-[1,2,4]Triazolo[4,3-A]Quinolin-7-Yl)Acetamides as Inotropic Agents 作者: Ye, BJ (Ye, Bai-Jun)[ 2 ] ; Liu, XK (Liu, Xue-Kun)[ 2 ] ; Jiang, SM (Jiang, Sheng-Ming)[ 2 ] ; Cui, X (Cui, Xun)[ 1 ] ; Piao, HR (Piao, Hu-Ri)[ 2 ] 来源出版物: CHEMICAL BIOLOGY & DRUG DESIGN 卷: 77 期: 1 页: 98-103 DOI: 10.1111/j.1747-0285.2010.01057.x 出版年: JAN 2011 被引频次: 3 (来自 Web of Science) 引用的参考文献: 10 [ 查看 Related Records ] 引证关系图引证关系图 摘要: In an attempt to search for more potent positive inotropic agents, a series of N-(4,5-dihydro-1-methyl-[1,2,4]triazolo[4,3-a]quinolin-7-yl)-2-(substitutedbenzyl-[1,4]diazepan-1-yl)acetamides were synthesized and evaluated for positive inotropic activity by measuring left atrium stroke volume in isolated rabbit heart preparations. Some of these derivatives exhibited favorable activity compared with the standard drug, milrinone, among which 2-(4-(4-methylbenzyl)-[1,4]-diazepan-1-yl)-N-(4,5-dihydro-1-methyl-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamide (6m) was the most potent, increasing stroke volume by 8.38 +/- 0.16% (milrinone 2.45 +/- 0.06%) at 3 x 10-5 m. The chronotropic effects of those compounds having inotropic effects were also evaluated in this work. 入藏号: WOS:000285065000012 文献类型: Article 语种: English 作者关键词: [1; 2; 4]triazolo[4; 3-a]quinolines; 1; 4-diazepan; positive inotropic activity; stroke volume KeyWords Plus: HEART-FAILURE; MORTALITY; VESNARINONE; ATRIA 通讯作者地址: Cui, X (通讯作者) Yanbian Univ, Coll Preclin Med, Yanji 133000, Peoples R China. 增强组织信息的名称 Yanbian University 地址: [ 1 ] Yanbian Univ, Coll Preclin Med, Yanji 133000, Peoples R China 增强组织信息的名称 Yanbian University [ 2 ] Yanbian Univ, Coll Pharm, Minist Educ, Key Lab Nat Resources Changbai Mt & Funct Mol, Yanji 133000, Peoples R China 增强组织信息的名称 Yanbian University 电子邮件地址: cuixun@ybu.edu.cn; piaohuri@yahoo.com.cn 基金资助致谢: 基金资助机构 授权号 National Natural Science Foundation of China 30560177 [显示基金资助信息][隐藏基金资助信息] This work was supported by the National Natural Science Foundation of China (No. 30560177). 出版商: WILEY-BLACKWELL PUBLISHING, INC, COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA Web of Science 类别: Biochemistry & Molecular Biology; Chemistry, Medicinal 研究方向: Biochemistry & Molecular Biology; Pharmacology & Pharmacy IDS 号: 691FF |
3楼2013-11-17 19:41:47
baiyuefei
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2楼2013-11-17 19:41:34
baiyuefei
版主 (文学泰斗)
风雪
- LS-EPI: 1647
- 应助: 4642 (副教授)
- 贵宾: 46.969
- 金币: 658104
- 散金: 11616
- 红花: 995
- 沙发: 81
- 帖子: 69424
- 在线: 13328.4小时
- 虫号: 676696
- 注册: 2008-12-18
- 性别: GG
- 专业: 合成药物化学
- 管辖: 有机交流
4楼2013-11-17 19:42:16
