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mlk008

木虫 (正式写手)

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虫号: 853485
注册: 2009-09-21
性别: GG
专业: 药剂学

[求助] 葡萄糖致瘤性和生殖毒性的关键两句看不懂

最近在写药理毒理的申报资料，其中有一项涉及葡萄糖，从drugfuture链接的化学物质毒性数据库中找到的葡萄糖的相关毒性，但是其中有几个地方看不懂；
（1）  ** TUMORIGENIC DATA **
TYPE OF TEST          : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE    : Subcutaneous
SPECIES OBSERVED       : Rodent - rat
DOSE/DURATION          : 15400 gm/kg/22W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
GANNA2 Gann.  Japanese Journal of Cancer Research.  (Tokyo, Japan)  V.1-75,
1907-84.  For publisher information, see JJCREP.  Volume(issue)/page/year:
30,419,1936
问：“Tumorigenic - equivocal tumorigenic agent by RTECS criteria”这句话是什么意思？ equivocal是模棱另可的意思，那这个致瘤性也不确定？
（2） ** REPRODUCTIVE DATA **
TYPE OF TEST          : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE    : Intravenous
SPECIES OBSERVED       : Human - woman
DOSE                   : 2 gm/kg
SEX/DURATION          : female 39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
BJOGAS British Journal of Obstetrics and Gynaecology.  (Blackwell Scientific
Pub. Ltd., POB 88, Oxford, UK)  V.82- 1975- Volume(issue)/page/year:
89,27,1982
问：“ Reproductive - Maternal Effects - other effects”，这句话该怎么翻译?百度 Maternal Effects 翻译为母体效应，后面又有个 other effects，这是在说什么啊？
(3) ** MUTATION DATA **
TYPE OF TEST          : Mutation in microorganisms
TEST SYSTEM          : Bacteria - Salmonella typhimurium
DOSE/DURATION          : 25 mg/plate
REFERENCE :
NARHAD Nucleic Acids Research. (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-  1974-
Volume(issue)/page/year: 12,2127,1984

TYPE OF TEST          : DNA damage
TEST SYSTEM          : Microorganism - not otherwise specified
DOSE/DURATION          : 150 mmol/L
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United States
of America.  (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.1- 1915-
Volume(issue)/page/year: 81,105,1984
问：致突变数据中，没有给出TOXIC EFFECTS，那这是有致突变性还是没有呢？