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卧马藏刀木虫 (正式写手)
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[求助]
基因多态性影响阿片类药物用量语段翻译，求助
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Moreover, of the 112 subjects there were 45 wild-type homozygotes CC, 49 heterozygotes CT and 18 mutant homozygotes TT. The frequency of ABCB1 C3435T allele was 37.94%. The sequencing results of the ABCB1 rs1045642 were showed in Figure 1. The distribution of ABCB1 C3435T allele was in Hardy-Weinberg equilibrium (p>0.05). The following study had failed to reveal any significant difference in 24h-opioids doses among the subjects carrying various ABCB1 allele phenotype (Table 4). Compared with the CC/CT phenotype, the subjects with TT homozygotes tended to require lower opioids intake dosage, but no significant statistical differences were observed (p=0.0057). However, when we measured using weight-surface area-adjusted-24h- opioids doses instead, the dosages of opioids administrated for the TT homozygotes was 0.60 ± 0.49 mg and significantly lower than those with CC/CT phenotypes (1.08 ± 0.88 mg , p=0.028). 本段文献主要讲的是ABCB1基因多态性对24小时阿片类药物用量（镇痛）的影响，“ weight-surface area-adjusted-24h- opioids doses”，这个名词不是很理解，“However, when we measured using weight-surface area-adjusted-24h- opioids doses instead, the dosages of opioids administrated for the TT homozygotes was 0.60 ± 0.49 mg and significantly lower than those with CC/CT phenotypes ”这句话我也翻译的很不到位（个人感觉），请大神们多多指教 |
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