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【答案】应助回帖
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shs912vv: 金币+120, 翻译EPI+1, ★★★★★最佳答案, 好厉害，基本是翻译出来的，还有少部分可能微调，而且大神貌似是跨专业的翻译哎~佩服佩服 2013-10-27 12:51:42
1.Foxm1b in regeneration G1 / S phase was significantly enhanced, Foxm1b mainly impacts on cell proliferation by regulating Skp2 and Cks1 in coding complex subunits of Skp-Cullin1-F-box (SCF) ubiquitin and ligase , targeting at the CDK to inhibit degradation of protein P21CIP1/WAF1, p27Kip in G1 / S phase conversion, thereby affecting activity certain Cyclin or Cdk activator Cdc25a, Cdc25b phosphatase, and he can activate JNK1, jointly regulate the transition of G1 / S. Foxm1b is also involved in process of the growth hormone (growth hormone, GH) mediating cell proliferation.
2.TGR5 can express on the surface of Kupffer cells , and after activation it can induce cell intracellular cyclic adenosine monophosphate (cyclic adenosine monophosphate, cAMP) to increase, by activating TGR5-cAMP pathway to improve the immune function of Kupffer cells to inhibit inflammatory cells to produce excessive factors affecting liver regeneration.
3.MAPKs are a class of serine / threonine protein kinase that regulates cell proliferation, apoptosis and other reactions. MAPKs mainly includ ERK, c-Jun N-terminal kinase (c-Jun NH2-terminal kinase, JNK) and p38MAPK pathway, among which JNK and p38MAKP are called stress-activated protein kinase. Studies have shown that low concentrations of acid can make JNK in liver cells increase significantly , while the high concentration of acid make the expression of p38MAPK protein significantly increase, suggesting that different concentrations of bile acids may effect on liver regeneration differently by regulating JNK and p38MAKP.
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