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[求助]
求细胞免疫相关的大神翻译3小段和肝再生细胞通路有关的话（已被精简）
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1.Foxm1b在肝细胞再生G1/S相表达显著增强, Foxm1b对细胞增殖的影响主要通过调控Skp2和Cks1编码Skp-Cullin1-F-box(SCF)泛素连接酶复合物的亚基, 靶向作用于CDK抑制蛋白P21CIP1/WAF1、p27Kip在G1/S相转换中降解, 进而影响某些Cyclin或Cdk活化剂Cdc25a、Cdc25b磷酸酶的活性, 同时他又能激活JNK1,共同调控G1/S的转变. Foxm1b还参与生长激素(growth hormone, GH)介导的细胞增殖. 2.TGR5可于Kupffer细胞表面表达, 活化后可诱导细胞内胞内环磷腺苷(cyclic adenosine monophosphate,cAMP)升高, 可通过激活TGR5-cAMP途径改善Kupffer细胞免疫功能, 抑制其产生过量的炎症细胞因子而影响肝再生. 3.MAPKs是一类丝氨酸/苏氨酸蛋白激酶, 可调节细胞增殖、凋亡等反应. MAPKs主要包括ERK、c-Jun氨基末端激酶(c-Jun NH2-terminal kinase, JNK)和p38MAPK通路,其中JNK和p38MAKP被称为应激活化蛋白激酶,. 有研究显示, 低浓度胆酸可使肝细胞JNK蛋白显著上调, 而高浓度的胆酸则使p38MAPK蛋白表达显著上调, 提示不同浓度的胆汁酸对肝再生的不同作用可能是通过调节JNK和p38MAKP途径实现的. |
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leilejiayou
木虫 (正式写手)
- 翻译EPI: 26
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shs912vv: 金币+120, 翻译EPI+1, ★★★★★最佳答案, 好厉害，基本是翻译出来的，还有少部分可能微调，而且大神貌似是跨专业的翻译哎~佩服佩服 2013-10-27 12:51:42
shs912vv: 金币+120, 翻译EPI+1, ★★★★★最佳答案, 好厉害，基本是翻译出来的，还有少部分可能微调，而且大神貌似是跨专业的翻译哎~佩服佩服 2013-10-27 12:51:42
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1.Foxm1b in regeneration G1 / S phase was significantly enhanced, Foxm1b mainly impacts on cell proliferation by regulating Skp2 and Cks1 in coding complex subunits of Skp-Cullin1-F-box (SCF) ubiquitin and ligase , targeting at the CDK to inhibit degradation of protein P21CIP1/WAF1, p27Kip in G1 / S phase conversion, thereby affecting activity certain Cyclin or Cdk activator Cdc25a, Cdc25b phosphatase, and he can activate JNK1, jointly regulate the transition of G1 / S. Foxm1b is also involved in process of the growth hormone (growth hormone, GH) mediating cell proliferation. 2.TGR5 can express on the surface of Kupffer cells , and after activation it can induce cell intracellular cyclic adenosine monophosphate (cyclic adenosine monophosphate, cAMP) to increase, by activating TGR5-cAMP pathway to improve the immune function of Kupffer cells to inhibit inflammatory cells to produce excessive factors affecting liver regeneration. 3.MAPKs are a class of serine / threonine protein kinase that regulates cell proliferation, apoptosis and other reactions. MAPKs mainly includ ERK, c-Jun N-terminal kinase (c-Jun NH2-terminal kinase, JNK) and p38MAPK pathway, among which JNK and p38MAKP are called stress-activated protein kinase. Studies have shown that low concentrations of acid can make JNK in liver cells increase significantly , while the high concentration of acid make the expression of p38MAPK protein significantly increase, suggesting that different concentrations of bile acids may effect on liver regeneration differently by regulating JNK and p38MAKP. 能力有限，仅供参考 |
2楼2013-10-27 12:24:33
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