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cainiaodui

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Notch ligands other than Dll4 may also affect tumor angiogenesis. For instance, Jagged1 expression was detected in clinical breast cancer samples, while pro-angiogenic, paracrine functions for Jagged1 in head and neck squamous cell carcinoma have also been suggested . Similarly, Jagged1 tumor angiogenesis-promoting effects were inferred in a mouse mammary tumor model . Of note in this context, opposing effects of Dll4 and Jagged1 on endothelial sprouting were recently reported in the retina angiogenesis model.Finally, Dll1 was implicated in the regulation of tumor angiogenesis in a fibroblast tumor model
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xux730

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cainiaodui: 金币+5, 翻译EPI+1 2013-09-25 10:20:42
Notch配体不同于DLL4,也会影响肿瘤的血管生成。例如,Jagged1的表达在乳腺癌临床样品检测到,而Jagged1的促血管生成和旁分泌功能也在头颈部鳞状细胞癌检测到。同样的,Jagged1促肿瘤血管生成的作用从小鼠乳腺肿瘤模型中推断得到。值得注意的是,在这种情况下, Dll4和Jagged1对内皮发芽的相反作用最近在视网膜血管生成模型上被报道。最后,成纤维细胞肿瘤模型提示DLL1调控肿瘤血管生成。
2楼2013-09-25 09:40:23
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