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| Notch ligands other than Dll4 may also affect tumor angiogenesis. For instance, Jagged1 expression was detected in clinical breast cancer samples, while pro-angiogenic, paracrine functions for Jagged1 in head and neck squamous cell carcinoma have also been suggested . Similarly, Jagged1 tumor angiogenesis-promoting effects were inferred in a mouse mammary tumor model . Of note in this context, opposing effects of Dll4 and Jagged1 on endothelial sprouting were recently reported in the retina angiogenesis model.Finally, Dll1 was implicated in the regulation of tumor angiogenesis in a fibroblast tumor model |
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