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The New Cassane-Type Diterpenes from Caesalpinia minax  
×÷Õß: Ma, GX (Ma, Guo-Xu)[ 1,2 ] ; Yuan, JQ (Yuan, Jing-Quan)[ 3 ] ; Cao, L (Cao, Li)[ 1,2 ] ; Yang, JS (Yang, Jun-Shan)[ 1,2 ] ; Xu, XD (Xu, Xu-Dong)[ 1,2 ]  
À´Ô´³ö°æÎï: CHEMICAL & PHARMACEUTICAL BULLETIN  ¾í: 60   ÆÚ: 6   Ò³: 759-763   ³ö°æÄê: JUN 2012  
±»ÒýƵ´Î: 0 (À´×Ô Web of Science)  
ÒýÓõIJο¼ÎÄÏ×: 19      [ ²é¿´ Related Records ]     ÒýÖ¤¹ØÏµÍ¼      
ÕªÒª: Four new cassane-type diterpenes, Neocaesalpin S (1), Neocaesalpin T (2), Neocaesalpin U (3), and Neocaesalpin V (4) were isolated from Caesalpinia minax HANCE together with seven known compounds Neocaesalpin A (5), Neocaesalpin K (6), Neocaesalpin L (7), Neocaesalpin M (8), Neocaesalpin 0 (9), Neocaesalpin MP (10), and Magnicaesalpin (11). Their structures were elucidated on the basis of 1D- and 2D-NMR, MS, and circular dichroism (CD) analysis. Compounds 1-4 were tested against liver cancer (HepG-2) and breast cancer (MCF-7), and showed mild antiproliferative activity.  
Èë²ØºÅ: WOS:000304727000010  
ÎÄÏ×ÀàÐÍ: Article  
ÓïÖÖ: English  
×÷Õ߹ؼü´Ê: Caesalpinia minax; cassane-type diterpene; antiproliferative activity  
KeyWords Plus: CRISTA L.; BONDUC; SEEDS; ALCOHOLS; FABACEAE; HANCE  
ͨѶ×÷ÕßµØÖ·: Xu, XD (ͨѶ×÷Õß) Peking Union Med Coll, Key Lab Bioact Subst & Resources Utilizat Chinese, Minist Educ, Inst Med Plant Dev, Beijing 100193, Peoples R China.
  ÔöÇ¿×éÖ¯ÐÅÏ¢µÄÃû³Æ
    Chinese Academy of Medical Sciences-Peking Union Medical College  

µØÖ·:  [ 1 ] Peking Union Med Coll, Key Lab Bioact Subst & Resources Utilizat Chinese, Minist Educ, Inst Med Plant Dev, Beijing 100193, Peoples R China
  ÔöÇ¿×éÖ¯ÐÅÏ¢µÄÃû³Æ
    Chinese Academy of Medical Sciences-Peking Union Medical College  
[ 2 ] Chinese Acad Med Sci, Beijing 100193, Peoples R China
  ÔöÇ¿×éÖ¯ÐÅÏ¢µÄÃû³Æ
    Chinese Academy of Medical Sciences
    Chinese Academy of Medical Sciences-Peking Union Medical College  
       [ 3 ] Guangxi Bot Garden Med Plant, Nanning 530023, Peoples R China

µç×ÓÓʼþµØÖ·: xdxu@implad.ac.cn  
»ù½ð×ÊÖúÖÂл:
»ù½ð×ÊÖú»ú¹¹ ÊÚȨºÅ
technological large platform for comprehensive research and development of new drugs in the Eleventh Five-Year "Significant New Drugs Created" Science and Technology Major Projects  2009ZX09301-003  
National Natural Science Foundation of China  30973626  
Science and Technology Grant of Guangxi Province  0639039  
Commonweal Academy and Institute of Central Authorities  YZ-1-24  
Innovation capacity-building in Guangxi Science and Technology Agency  0443002-2  

[ÏÔʾ»ù½ð×ÊÖúÐÅÏ¢][Òþ²Ø»ù½ð×ÊÖúÐÅÏ¢]   

The work was supported by the technological large platform for comprehensive research and development of new drugs in the Eleventh Five-Year "Significant New Drugs Created" Science and Technology Major Projects (No. 2009ZX09301-003). National Natural Science Foundation of China (No. 30973626), the Science and Technology Grant of Guangxi Province (No. 0639039) and special purpose of basic scientific research operation grant for Commonweal Academy and Institute of Central Authorities (No. YZ-1-24). Innovation capacity-building in Guangxi Science and Technology Agency (0443002-2).

³ö°æÉÌ: PHARMACEUTICAL SOC JAPAN, 2-12-15-201 SHIBUYA, SHIBUYA-KU, TOKYO, 150, JAPAN  
Web of Science Àà±ð: Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology & Pharmacy  
Ñо¿·½Ïò: Pharmacology & Pharmacy; Chemistry  
IDS ºÅ: 951NJ  
ISSN: 0009-2363
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