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| There have been some notable clinical successes attributed to VEGF blockade, and Avastin is approved for treatment of colon and renal cancers; however, many cancers that clearly require vascularization are highly resistant to VEGF-A blockade from the start. In addition, many others acquire such resistance, casting some doubt both on the therapeutic benefit of VEGF-A blockade and on the factor’s indispensability in angiogenesis. Drug developers have more recently sought to target other known angiogenic pathways, pursuing therapies that might be useful independently or in concert with VEGF blockade in the treatment of cancer. |
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