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cainiaodui

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In clinical breast cancer samples DLL4 was expressed by intratumoral endothelial cells (almost 100%) and cells of ductal carcinomas. High intensity of DLL4 endothelial expression was astatistically significant adverse prognostic factor, which may suggest that breast tumors with high DLL4 expression in the vasculature progressed more rapidly. In contrast to the case of bladder and breast cancer, endothelial expression of DLL4 in colon cancer should not be considered as aprognostic factor. The expression of DLL4 in colon cancer tissues was observed preferentially in endothelium and, what is not surprising, was significantly associated with expression of VEGF
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xux730

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cainiaodui: 金币+5, 翻译EPI+1 2013-09-22 09:59:44
在乳腺癌临床样本中,DLL4由瘤内内皮细胞(几乎100%)和乳腺导管癌细胞表达。DLL4在内皮细胞的高强度表达是乳腺癌的不良预后因子(统计学上有显著性),提示在血管丛中DLL4高表达的乳腺癌进展快速。与膀胱癌和乳腺癌不同,DDL4在结肠癌内皮细胞的高表达不应该被认为是不良预后因子。结肠癌组织中DLL4的表达倾向于在内皮,而且不令人惊讶地与血管内皮生长因子的表达显着相关。
2楼2013-09-22 09:29:02
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