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| In clinical breast cancer samples DLL4 was expressed by intratumoral endothelial cells (almost 100%) and cells of ductal carcinomas. High intensity of DLL4 endothelial expression was astatistically significant adverse prognostic factor, which may suggest that breast tumors with high DLL4 expression in the vasculature progressed more rapidly. In contrast to the case of bladder and breast cancer, endothelial expression of DLL4 in colon cancer should not be considered as aprognostic factor. The expression of DLL4 in colon cancer tissues was observed preferentially in endothelium and, what is not surprising, was significantly associated with expression of VEGF |
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