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1949stone

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[资源] HUMAN GENETICS: Race, Population, and Disease

Foreword x
Preface xiii
Acknowledgments xvi
Introduction xvii
1 From Genes to Human Beings 1
Mendel and the Laws of Heredity 1
Cells, Chromosomes, and Sex 6
Discovering and Mapping Genes 10
From Genotype to Phenotype 14
Stem Cells and Development 17
Mutations 20
Making Blood in the Lab 21
2 The Evolution of the Human Genome 30
The Origins of the Genome 31
Traces of the Early Evolution of Animals 37
Molecular Clocks 44
Comparing the Chimpanzee and Human
Genomes 47
The Search for the Earliest Hominid 48
The Evolution of the Human Brain 54
Mitochondrial Eve and Y-Chromosomal
Adam 61
Populating the Globe 70
What Happened to the Neanderthals? 71
3 Using Genetics to Solve Ancient
Mysteries and Modern Crimes 81
Ötzi’s Granddaughter 82
Contents
The Origins of the Basques 85
Making a Pedigree 90
The Heirs of Thomas Jefferson 92
The Grave of Jesse James 95
The Fate of Anastasia, Grand Duchess
of Russia 98
4 The Genetics of Health and Disease 104
Finding Disease Genes 106
Multifactorial Diseases 110
Diagnosis and Genetic Counseling 113
Learning to Repair Defective Genes 117
The Genetics of Cancer 120
Stem Cells and Cancer 123
Mary-Claire King: Cancer Pioneer and Activist 125
Chernobyl and Its Impact on the Human
Genome 130
Genes of the Adaptive Immune System 134
Pharmacogenetics and the Development
of Individualized Medicine 139
5 The Genetics of Behavior, Human
Diversity, and Society 142
The Science and Politics of Human Diversity 143
Evolutionary Psychology 148
Twin Studies and the Genetics of IQ 156
The Genetics of Cognitive Disorders 160
Kim Peek and the Savants 166
Human Adaptation and Competition
between Societies 169
Conclusion: A Look into the Future:
The Genetic Engineering of
Human Beings? 174
Chronology 179
Glossary 193
Further Resources 203
Index

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