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HUMAN GENETICS: Race, Population, and Disease
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 Foreword x Preface xiii Acknowledgments xvi Introduction xvii 1 From Genes to Human Beings 1 Mendel and the Laws of Heredity 1 Cells, Chromosomes, and Sex 6 Discovering and Mapping Genes 10 From Genotype to Phenotype 14 Stem Cells and Development 17 Mutations 20 Making Blood in the Lab 21 2 The Evolution of the Human Genome 30 The Origins of the Genome 31 Traces of the Early Evolution of Animals 37 Molecular Clocks 44 Comparing the Chimpanzee and Human Genomes 47 The Search for the Earliest Hominid 48 The Evolution of the Human Brain 54 Mitochondrial Eve and Y-Chromosomal Adam 61 Populating the Globe 70 What Happened to the Neanderthals? 71 3 Using Genetics to Solve Ancient Mysteries and Modern Crimes 81 Ötzi’s Granddaughter 82 Contents The Origins of the Basques 85 Making a Pedigree 90 The Heirs of Thomas Jefferson 92 The Grave of Jesse James 95 The Fate of Anastasia, Grand Duchess of Russia 98 4 The Genetics of Health and Disease 104 Finding Disease Genes 106 Multifactorial Diseases 110 Diagnosis and Genetic Counseling 113 Learning to Repair Defective Genes 117 The Genetics of Cancer 120 Stem Cells and Cancer 123 Mary-Claire King: Cancer Pioneer and Activist 125 Chernobyl and Its Impact on the Human Genome 130 Genes of the Adaptive Immune System 134 Pharmacogenetics and the Development of Individualized Medicine 139 5 The Genetics of Behavior, Human Diversity, and Society 142 The Science and Politics of Human Diversity 143 Evolutionary Psychology 148 Twin Studies and the Genetics of IQ 156 The Genetics of Cognitive Disorders 160 Kim Peek and the Savants 166 Human Adaptation and Competition between Societies 169 Conclusion: A Look into the Future: The Genetic Engineering of Human Beings? 174 Chronology 179 Glossary 193 Further Resources 203 Index |
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2013-08-27 12:57:42, 10.93 M
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