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Counterions.  If your compound is ionic, and is not giving suitable crystals with a given counterion, perform a metathesis reaction to change the counterion.  Very often the crystal quality will improve when a different counterion used.  Ions of similar size tend to pack together better and subsequently give better crystals.  In addition, you might also get more desirable physical properties for your crystal.  For example, the sodium salt of your compound might be hygroscopic, but the tetramethyl ammonium salt might not be or at least, less so.  When selecting possible counterions, avoid ions which contain large non-rigid groups (like tetrabutyl ammonium).  Use ions which have very limited conformational flexibility.  A word of warning:  make sure that whatever ion you use for your metathesis does not react with your ion of interest.
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