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[资源] Reverse Transcriptase Inhibitors in HIV/AIDS Therapy

Reverse Transcriptase Inhibitors in HIV/AIDS Therapy (Infectious Disease)
By Gail Skowron

Publisher:  Humana Press
Number Of Pages:  544
Publication Date:  2006-05-01
ISBN / ASIN:  1588296490

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Book Description:

A magisterial survey of all aspects of the reverse transcriptase inhibitors (RTIs) used to treat HIV/AIDS, including drug discovery, pharmacology, development of drug resistance, toxicity, and prevention of mother-to-child transmission of HIV/AIDS. The authors synthesize our current understanding of the role of reverse transcriptase in the viral life cycle, describe the discovery and development of eight nucleoside and nucleotide analogs that represent milestones in treatment history, and thoroughly discuss the question of toxicity and resistance to this class of drugs. They also address three non-nucleoside RTIs and their pharmacokinetics and comparative clinical efficacy, new RTIs currently under development, and the impact of approved agents on treatment, in general, and on vertical transmission in the developing world.

1 Structural Studies on HIV Reverse Transcriptase
Related to Drug Discovery
David K. Stammers, PhD and Jingshan Ren, PhD......................... 1
2 Zidovudine, Lamivudine, and Abacavir
Monica Carten, MD and Harold Kessler, MD ............................. 33
3 Stavudine, Didanosine, and Zalcitabine
Gail Skowron, MD, Sapna Chowdhry, MD,
and Michael R. Stevens, PharmD ............................................... 77
4 Emtricitabine
Gail Skowron, MD, Jeffrey Bratberg, PharmD, BCPS,
and Rudi Pauwels, PhD ........................................................... 133
5 Nucleotide Analogs
Craig J. Hoesley, MD .................................................................... 157
6 Resistance to Nucleoside and Nucleotide Reverse
Transcriptase Inhibitors
Nancy Shulman, MD and Mark Winters, MS ........................... 179
7 Pharmacokinetics of Reverse Transcriptase Inhibitors
Patrick Hoggard, PhD, Stephen Kewn, PhD,
Saye Khoo, MD, PhD, and David Back, PhD ........................... 209
8 Peripheral Neuropathy Associated With Nucleoside
Reverse Transcriptase Inhibitor Therapy
Bruce A. Cohen, MD and Russell Bartt, MD .............................. 237
x Contents
9 Mitochondrial Dysfunction and Nucleoside Reverse
Transcriptase Inhibitor Therapy:
A Pathophysiological Perspective
William Lewis, MD....................................................................... 267
10 Mitochondrial Toxicity and Lipodystrophy
Grace McComsey, MD .................................................................. 281
11 Nevirapine
David Asmuth, MD, and Richard Pollard, MD......................... 303
12 Efavirenz
Graeme J. Moyle, MD, MBBS and Brian Conway, MD............... 345
13 Delavirdine
Brian Conway, MD ....................................................................... 375
14 Resistance to Non-Nucleoside Reverse Transcriptase
Inhibitors
F. Ramzi Asfour, MD and Richard Haubrich, MD.................... 401
15 Vertical Transmission of HIV and Therapeutic
Interventions
Susan Cu-Uvin, MD, Arlene Bardeguez, MD, MPH,
and Carla Chibwesha, MSc ........................................................ 425
16 New Reverse Transcriptase Inhibitors in Development
Rudi Pauwels, PhD ....................................................................... 471
17 Antiretroviral Drugs for Millions
Allan Ronald, MD, Elly Katabira, MBBS,
and Merle Sande, MD ............................................................... 499
Postscript
Richard Ogden, PhD and Gail Skowron, MD ............................ 515
Index .............................................................................................. 517
http://www.91files.com/?1F8M6R8UA4PHFW5YMAPJ

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