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Reverse Transcriptase Inhibitors in HIV/AIDS Therapy
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Reverse Transcriptase Inhibitors in HIV/AIDS Therapy (Infectious Disease) By Gail Skowron Publisher: Humana Press Number Of Pages: 544 Publication Date: 2006-05-01 ISBN / ASIN: 1588296490 -------------------------------------------------------------------------------- Book Description: A magisterial survey of all aspects of the reverse transcriptase inhibitors (RTIs) used to treat HIV/AIDS, including drug discovery, pharmacology, development of drug resistance, toxicity, and prevention of mother-to-child transmission of HIV/AIDS. The authors synthesize our current understanding of the role of reverse transcriptase in the viral life cycle, describe the discovery and development of eight nucleoside and nucleotide analogs that represent milestones in treatment history, and thoroughly discuss the question of toxicity and resistance to this class of drugs. They also address three non-nucleoside RTIs and their pharmacokinetics and comparative clinical efficacy, new RTIs currently under development, and the impact of approved agents on treatment, in general, and on vertical transmission in the developing world. 1 Structural Studies on HIV Reverse Transcriptase Related to Drug Discovery David K. Stammers, PhD and Jingshan Ren, PhD......................... 1 2 Zidovudine, Lamivudine, and Abacavir Monica Carten, MD and Harold Kessler, MD ............................. 33 3 Stavudine, Didanosine, and Zalcitabine Gail Skowron, MD, Sapna Chowdhry, MD, and Michael R. Stevens, PharmD ............................................... 77 4 Emtricitabine Gail Skowron, MD, Jeffrey Bratberg, PharmD, BCPS, and Rudi Pauwels, PhD ........................................................... 133 5 Nucleotide Analogs Craig J. Hoesley, MD .................................................................... 157 6 Resistance to Nucleoside and Nucleotide Reverse Transcriptase Inhibitors Nancy Shulman, MD and Mark Winters, MS ........................... 179 7 Pharmacokinetics of Reverse Transcriptase Inhibitors Patrick Hoggard, PhD, Stephen Kewn, PhD, Saye Khoo, MD, PhD, and David Back, PhD ........................... 209 8 Peripheral Neuropathy Associated With Nucleoside Reverse Transcriptase Inhibitor Therapy Bruce A. Cohen, MD and Russell Bartt, MD .............................. 237 x Contents 9 Mitochondrial Dysfunction and Nucleoside Reverse Transcriptase Inhibitor Therapy: A Pathophysiological Perspective William Lewis, MD....................................................................... 267 10 Mitochondrial Toxicity and Lipodystrophy Grace McComsey, MD .................................................................. 281 11 Nevirapine David Asmuth, MD, and Richard Pollard, MD......................... 303 12 Efavirenz Graeme J. Moyle, MD, MBBS and Brian Conway, MD............... 345 13 Delavirdine Brian Conway, MD ....................................................................... 375 14 Resistance to Non-Nucleoside Reverse Transcriptase Inhibitors F. Ramzi Asfour, MD and Richard Haubrich, MD.................... 401 15 Vertical Transmission of HIV and Therapeutic Interventions Susan Cu-Uvin, MD, Arlene Bardeguez, MD, MPH, and Carla Chibwesha, MSc ........................................................ 425 16 New Reverse Transcriptase Inhibitors in Development Rudi Pauwels, PhD ....................................................................... 471 17 Antiretroviral Drugs for Millions Allan Ronald, MD, Elly Katabira, MBBS, and Merle Sande, MD ............................................................... 499 Postscript Richard Ogden, PhD and Gail Skowron, MD ............................ 515 Index .............................................................................................. 517 http://www.91files.com/?1F8M6R8UA4PHFW5YMAPJ |
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