| 查看: 396 | 回复: 1 | |||
| 本帖产生 1 个 翻译EPI ，点击这里进行查看 | |||
yin198716新虫 (正式写手)
|
[求助]
求助翻译
|
||
|
DLL4 is a ligand for the Notch family of receptors. DLL4 has many important functions in normal development and tissue homeostasis, including roles in the immune system, the gastro-intestinal tract, and in vascular development. Because of the importance of Notch signaling in stem cell biology, DLL4 has been investigated for its role in the maintenance and proliferation of cancer stem cells (CSC) . In addition, its important role in angiogenesis has been investigate d for utility as an anti-angiogenic agent. Preclinical studies have highlighted that both anti-CSC and anti-angiogenic activities contribute to its anti-tumor efficacy, and have supported the clinical development of anti-DLL4 antibody for the treatment of cancer |
回复此楼» 猜你喜欢
急需调剂
已经有8人回复
-
申博/考博
已经有4人回复
-
化工学硕294分，求导师收留
已经有37人回复
-
求调剂
已经有11人回复
-
260求调剂
已经有4人回复
-
一志愿华中农业071010，320求调剂
已经有19人回复
-
304求调剂
已经有7人回复
-
求博导｜生物质基多孔碳/超级电容方向，已有相关成果，寻能源材料/碳材料方向老师
已经有3人回复
-
二苯甲酮酸类衍生物
已经有6人回复
-
接受任何调剂
已经有4人回复
fuboluben
铁杆木虫 (小有名气)
- 翻译EPI: 51
- 应助: 2 (幼儿园)
- 金币: 5949.4
- 散金: 8
- 红花: 2
- 帖子: 143
- 在线: 143.9小时
- 虫号: 1148022
- 注册: 2010-11-16
- 专业: 微生物药物
【答案】应助回帖
★ ★ ★ ★ ★
yin198716: 金币+5, 翻译EPI+1, In addition, its important role in angiogenesis has been investigate d for utility as an anti-angiogenic agent. 好像没有翻译 大哥 2013-07-02 10:56:02
yin198716: 金币+5, 翻译EPI+1, In addition, its important role in angiogenesis has been investigate d for utility as an anti-angiogenic agent. 好像没有翻译 大哥 2013-07-02 10:56:02
|
DII4是一种内皮特异性配体，其通常在血管发育及血管生成部位表达。已经证实，在乳腺癌、肾癌、膀胱癌的血管分布中，DII4的表达会明显上调。 DII4是NOTCH家族受体的配体。DII4在正常发育和组织体内平衡如免疫系统、胃肠道及血管生成等方面具有重要作用。 由于在干细胞生物学中，Notch信号有非常重要的作用，因此已有许多研究对DLL4在癌症干细胞增殖及维持方面的作用进行了考察。 临床前研究显著证实抗CSC与抗血管生成活性均有抗肿瘤效果，而且这一研究对抗DLL4抗体在癌症治疗方面的临床发展具有重要的支持作用。 |
2楼2013-07-02 08:02:05
20