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DLL4 is a ligand for the Notch family of receptors. DLL4 has many important functions in normal development and tissue homeostasis, including roles in the immune system, the gastro-intestinal tract, and in vascular development. Because of the importance of Notch signaling in stem cell biology, DLL4 has been investigated for its role in the maintenance and proliferation of cancer stem cells (CSC) . In addition, its important role in angiogenesis has been investigate d for utility as an anti-angiogenic agent. Preclinical studies have highlighted that both anti-CSC and anti-angiogenic activities contribute to its anti-tumor efficacy, and have supported the clinical development of anti-DLL4 antibody for the treatment of cancer |
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yin198716: 金币+5, 翻译EPI+1, In addition, its important role in angiogenesis has been investigate d for utility as an anti-angiogenic agent. 好像没有翻译 大哥 2013-07-02 10:56:02
yin198716: 金币+5, 翻译EPI+1, In addition, its important role in angiogenesis has been investigate d for utility as an anti-angiogenic agent. 好像没有翻译 大哥 2013-07-02 10:56:02
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DII4是一种内皮特异性配体，其通常在血管发育及血管生成部位表达。已经证实，在乳腺癌、肾癌、膀胱癌的血管分布中，DII4的表达会明显上调。 DII4是NOTCH家族受体的配体。DII4在正常发育和组织体内平衡如免疫系统、胃肠道及血管生成等方面具有重要作用。 由于在干细胞生物学中，Notch信号有非常重要的作用，因此已有许多研究对DLL4在癌症干细胞增殖及维持方面的作用进行了考察。 临床前研究显著证实抗CSC与抗血管生成活性均有抗肿瘤效果，而且这一研究对抗DLL4抗体在癌症治疗方面的临床发展具有重要的支持作用。 |
2楼2013-07-02 08:02:05