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fdfdsos

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[求助] 求助翻译

所以，我们寻找对接位点的目标在于搜索我们目的蛋白构建的模型中是否有与晶体结构类似的ACH结合口袋。虽然目标蛋白和模板蛋白的序列一致性仅为27%，但是三级结构通常会比一级结构保守很多。根据目标蛋白和模板蛋白的三维结构叠合图，我们比较了两者的ACH结合位点，结果如图5所示。由图中可以看出，由于目标蛋白的序列比模板蛋白的A链长出一部分，导致部分序列不能找到合适的模板，这也可能是影响模型质量的一个因素，但是在ACH的结合区域，两者的三维结构相似性非常高，ACH的结合位点基本重合，表明利用该模型进行进一步的对接研究是合理的。

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1楼 2013-06-01 17:53:06

已阅关注TA 给TA发消息送TA红花 TA的回帖

l419110028

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【答案】应助回帖

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感谢参与，应助指数 +1
zhtear99: 金币+3, 感谢热心应助，翻译的还蛮好。BB奖励下，欢迎常来~~ 2013-06-03 23:01:20
fdfdsos: 金币+100, ★★★★★最佳答案, good ，很好 2013-06-04 15:21:22

So, we are looking for docking sites Search our goal is to build a model of the target protein and crystal structure have similar ACH binding pocket. Although the target protein and the template protein sequence identity of only 27%, but the three structures are usually conservative than a lot of structure. The target protein and a three-dimensional structure of proteins superimposed templates diagram ACH we compare the two binding sites, shown in Figure 5. As can be seen from the figure, because the target protein sequence of the protein than the template part of the A chain to grow, resulting in some sequence can not find a suitable template, which affect the quality of the model may also be a factor, but in the binding region of ACH, two The three-dimensional structure by a very high similarity, ACH is coincident binding sites, show that the use of the model for further Docking is reasonable.