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karl2100: ½ð±Ò+1, лл£¡ 2013-05-03 23:27:39
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2Â¥2013-05-03 11:08:19
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2Â¥: Originally posted by chem_sq at 2013-05-03 11:08:19
Cmax:Ѫҩ´ï·åŨ¶È
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3Â¥: Originally posted by ÑôÑòyyy at 2013-05-03 16:28:08
ÎÒ˵µÄÊÇCmax/AUCµÄ±ÈÖµÓÐʲô×÷ÓÃŶ...

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4Â¥2013-05-04 22:13:53
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5Â¥2013-05-06 10:06:25
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Endrenyi and co-workers (1991, 1993) were the first to show that Cmax/AUC is a
better characteristic of the absorption rate than Cmax itself. They showed that the ratio
Cmax/AUC is independent of both within-subject variations and possible differences in
the extent of absorption and ¨C in the case of a one-compartment body model with firstorder
absorption ¨C reflects only the contrast between the absorption and disposition rate
constants, ka/kel. Lacey et al. (1994) considered simulated and real experiments and came
up with the conclusion that Cmax/AUC is a more powerful metric than Cmax in establishing
bioequivalence when formulations are truly bioequivalent, and that Cmax/AUC is more
sensitive than Cmax at detecting differences in rate of absorption when they exist. Schall
and co-workers (1994) showed that under fairly general conditions tmax and Cmax/AUC
are equivalent characteristics of the absorption rate. Cmax/AUC can be observed with
higher precision, and is easier to handle statistically than tmax. On the basis of data from
20 bioequivalence studies they came up with the rather subtle recommendation that for
drugs with short (<5 hours) elimination half-lives or fastest disposition half-lives in the
case of higher compartmental models, Cmax/AUC is the best rate characteristic, but that
for drugs with long elimination or fastest disposition half-lives, tmax can be superior to
Cmax/AUC.
6Â¥2013-05-14 08:48:19
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