| 查看: 6331 | 回复: 6 | ||
[求助]
请问Cmax/AUC这个参数有什么作用 已有1人参与
|
| 请教各位：Cmax/AUC这个参数有什么作用？可以用来衡量药物吸收率吗？为什么？谢谢各位了 |
回复此楼» 猜你喜欢
0703化学调剂，求各位老师收留
已经有8人回复
-
070303一志愿西北大学学硕310找调剂
已经有8人回复
-
085600材料与化工 求调剂
已经有14人回复
-
本人考085602 化学工程 专硕
已经有13人回复
-
材料与化工求调剂
已经有3人回复
-
283求调剂
已经有13人回复
-
312求调剂
已经有4人回复
-
285求调剂
已经有6人回复
-
材料与化工专硕调剂
已经有3人回复
-
0703化学调剂 ，六级已过，有科研经历
已经有6人回复
» 本主题相关价值贴推荐，对您同样有帮助:
- 求助：AUC和生物利用度之间怎么换算啊？一个药物在体内的生物利用度达到80%算高吗？
已经有3人回复
- 静脉滴注与口服给药的区别
已经有9人回复
- 药物非线性吸收
已经有14人回复
- 求助治疗抑郁的欣百达(盐酸度洛西汀肠溶胶囊的说明书，最好是PDF版本的！
已经有8人回复
- 【讨论】药物暴露
已经有10人回复
- 【分享】请教药理学方面的前辈
已经有12人回复
chem_sq
木虫 (著名写手)
- 应助: 84 (初中生)
- 金币: 4096.5
- 红花: 11
- 帖子: 2116
- 在线: 345.5小时
- 虫号: 770390
- 注册: 2009-05-14
- 性别: GG
- 专业: 合成药物化学
2楼2013-05-03 11:08:19
3楼2013-05-03 16:28:08
星星的眼睛
铁杆木虫 (著名写手)
- PhEPI: 1
- 应助: 1634 (讲师)
- 金币: 7796.8
- 红花: 41
- 帖子: 2694
- 在线: 824.5小时
- 虫号: 2261661
- 注册: 2013-01-26
- 专业: 药剂学
4楼2013-05-04 22:13:53
zhoupeng87
版主 (文学泰斗)
- 应助: 6148 (副教授)
- 贵宾: 8.516
- 金币: 47410.3
- 散金: 58001
- 红花: 566
- 沙发: 2391
- 帖子: 64964
- 在线: 9636.5小时
- 虫号: 962700
- 注册: 2010-03-06
- 性别: GG
- 专业: 无机材料化学
- 管辖: 精细化工
5楼2013-05-06 10:06:25
zhangxuan200
铁杆木虫 (正式写手)
- PhEPI: 2
- 应助: 101 (高中生)
- 金币: 11138
- 红花: 6
- 帖子: 311
- 在线: 559.7小时
- 虫号: 95949
- 注册: 2005-10-07
- 性别: GG
- 专业: 药物分析
【答案】应助回帖
|
Endrenyi and co-workers (1991, 1993) were the first to show that Cmax/AUC is a better characteristic of the absorption rate than Cmax itself. They showed that the ratio Cmax/AUC is independent of both within-subject variations and possible differences in the extent of absorption and – in the case of a one-compartment body model with firstorder absorption – reflects only the contrast between the absorption and disposition rate constants, ka/kel. Lacey et al. (1994) considered simulated and real experiments and came up with the conclusion that Cmax/AUC is a more powerful metric than Cmax in establishing bioequivalence when formulations are truly bioequivalent, and that Cmax/AUC is more sensitive than Cmax at detecting differences in rate of absorption when they exist. Schall and co-workers (1994) showed that under fairly general conditions tmax and Cmax/AUC are equivalent characteristics of the absorption rate. Cmax/AUC can be observed with higher precision, and is easier to handle statistically than tmax. On the basis of data from 20 bioequivalence studies they came up with the rather subtle recommendation that for drugs with short (<5 hours) elimination half-lives or fastest disposition half-lives in the case of higher compartmental models, Cmax/AUC is the best rate characteristic, but that for drugs with long elimination or fastest disposition half-lives, tmax can be superior to Cmax/AUC. |
6楼2013-05-14 08:48:19
7楼2014-05-25 18:18:23
