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Adult mongrel dogs which had been anesthetized by the intravenous administration of 30-40mg/kg of pentobarbital sodium were subjected to thoracotomy under oxygenic ventilation by use of Bird¡¯s respirator and thereafter various physical phenomena were measured in the following manner. Diastolic coronary flow began to increase 10-20 seconds after the intravenous administration of the test compound with a dose of 10 ug/kg or more. Systolic coronary flow was increased with a dose of 250 ug/kg or more, accompanied by transient decrease just after the administration. Mean coronary flow showed a persistent increase after the administration of the test compound. |
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