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【答案】应助回帖
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眼淚成詩: 金币+50, 翻译EPI+1, ★★★★★最佳答案, 谢谢，用的女朋友的号 2013-04-22 08:48:59
眼淚成詩: 金币+50, ★★★★★最佳答案, 再次感谢 2013-04-22 09:35:19
采用的实验方法：（1）采用复乳法（W/O/W）和乳化溶剂挥发法（O/W）分别制备奥沙利铂PLA纳米粒、吉西他滨PLA纳米粒和紫杉醇PLA纳米粒，对两种制备方法中影响纳米粒粒径和载药率的因素进行单因素考察，筛选出较好的水平设计正交实验，优化得到最佳制备工艺。通过透射电子显微镜（TEM）和Zeta电位及激光粒度分析仪对纳米粒形貌和粒径进行表征；
Experimental methods: (1) both double emulsion (W/O/W) and emulsion solvent evaporation method (O/W) were employed for Preparation of oxaliplatin PLA nanoparticles, the gemcitabine PLA nanoparticles and paclitaxel PLA nanoparticles, the influence factor of two preparation methods on nanoparticles size and drug loading rate were investigated via single factor investigation, the best orthogonal experiment design achieved, and the preparation process was optimized. nanoparticle morphology and nanoparticle size were characterized through transmission electron microscopy(TEM) and Zeta potential characterization and laser particle size analyzer;
过酰胺化反应分别将FA和HA偶联到PLA载药纳米粒表面，考察不同反应条件对配体偶联量的影响并找出最佳偶联工艺。红外光谱（IR）表征配体偶联情况，Zeta电位及激光粒度分析仪和扫描电子显微镜（SEM）对偶联配体后的纳米粒粒径和形貌进行表征；
FA and HA were coupled on the surface of the PLA drug-loaded nanoparticles through amidation reaction, the optimal amidation process was determined through analysis of the influence of various reaction condition on the amount of ligand coupling. Ligand coupling was characterized though Infrared spectroscopy (IR), nanoparticle size and nanoparticle morphology were characterized through scanning electron microscopy(SEM) and Zeta potential characterization and laser particle size analyzer
今天比较晚了，明天再帮你整一下剩下的，我整理的不一定完全正确，仅供楼主参考，不过有个别句子楼主的汉语也存在一定的问题 ，希望楼主再多读几遍，完善一下。 |
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