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yin198716新虫 (正式写手)
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| The feedback loop between VEGF and Notch involves regulation of all VEGFRs by Notch. VEGF/VEGFR2 enhances DLL4 expression in tip cells. DLL4-mediated activation of Notch in neighboring ECs inhibits tip cell behavior in these cells by downregulating VEGFR2, VEGFR3, and NRP1 while upregulating VEGFR1. Computational modeling indicates that such an integrated negative feedback loop of VEGF and Notch is sufficient to establish a stable pattern of tip and stalk cells. |
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Rio2016
木虫 (小有名气)
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【答案】应助回帖
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phu_grassman: 金币+3, good job. 2013-04-12 08:51:07
yin198716: 金币+20, 翻译EPI+1, ★有帮助 2013-04-20 13:42:40
phu_grassman: 金币+3, good job. 2013-04-12 08:51:07
yin198716: 金币+20, 翻译EPI+1, ★有帮助 2013-04-20 13:42:40
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The feedback loop between VEGF and Notch involves regulation of all VEGFRs by Notch. VEGF和Notch间的反馈回路涉及Notch对所有VEGF受体的调控。 VEGF/VEGFR2 enhances DLL4 expression in tip cells. VEGF/VEGFR2 相互作用会增强顶细胞中 DLL4 的表达。 DLL4-mediated activation of Notch in neighboring ECs inhibits tip cell behavior in these cells by downregulating VEGFR2, VEGFR3, and NRP1 while upregulating VEGFR1. 附近ECs 中DLL4介导性的Notch激活，会通过在ECs 中下调VEGFR2、VEGFR3、NRP1和上调 VEGFR1以抑制顶细胞的行为。 Computational modeling indicates that such an integrated negative feedback loop of VEGF and Notch is sufficient to establish a stable pattern of tip and stalk cells. 计算模型表明，这样一个关于VEGF和Notch的集成负反馈环就足够建立一个关于顶细胞和柄细胞的稳定模式。 |
2楼2013-04-11 19:01:03
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