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yin198716

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The feedback loop between VEGF and Notch involves regulation of all VEGFRs by Notch. VEGF/VEGFR2 enhances DLL4 expression in tip cells. DLL4-mediated activation of Notch in neighboring ECs inhibits tip cell behavior in these cells by downregulating VEGFR2, VEGFR3, and NRP1 while upregulating VEGFR1. Computational modeling indicates that such an integrated negative feedback loop of VEGF and Notch is sufficient to establish a stable pattern of tip and stalk cells.

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Oncology
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phu_grassman: ½ð±Ò+3, good job. 2013-04-12 08:51:07
yin198716: ½ð±Ò+20, ·­ÒëEPI+1, ¡ïÓаïÖú 2013-04-20 13:42:40
The feedback loop between VEGF and Notch involves regulation of all VEGFRs by Notch.
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DLL4-mediated activation of Notch in neighboring ECs inhibits tip cell behavior in these cells by downregulating VEGFR2, VEGFR3, and NRP1 while upregulating VEGFR1.
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Computational modeling indicates that such an integrated negative feedback loop of VEGF and Notch is sufficient to establish a stable pattern of tip and stalk cells.
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