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| Mutations of the Jagged1and Notch3 genes in humans lead to the autosomal dominantdisorders Alagille syndrome and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy,respectively, both of which exhibit severe vascular defects .Mice deficient for a variety of components of the Notch path-way display embryonic lethality with severe vascular abnormalities |
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yin198716: ½ð±Ò+5, ·ÒëEPI+1, ¡ïÓаïÖú 2013-03-31 15:33:04
yin198716: ½ð±Ò+5, ·ÒëEPI+1, ¡ïÓаïÖú 2013-03-31 15:33:04
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Mutations of the Jagged1and Notch3 genes in humans lead to the autosomal dominantdisorders Alagille syndrome and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy,respectively, both of which exhibit severe vascular defects . ÈËÀàµÄJagged1ºÍNotch3»ùÒòÍ»±ä»áµ¼Ö ³£È¾É«ÌåÏÔÐÔÒì³£°¬Å·¼ªÀÕ×ÛºÏÕ÷ ºÍ ³£È¾É«ÌåÏÔÐÔÒÅ´«ÄÔ¶¯Âö²¡£¨°éÓÐÆ¤²ãϹ£ËÀºÍÄÔ°×Öʲ¡±ä£©£¬ËüÃDZíÏÖ³öÑÏÖØµÄѪ¹Üȱ·¦¡£ Mice deficient for a variety of components of the Notch path-way display embryonic lethality with severe vascular abnormalities NotchÐźÅͨ·Öи÷ÖÖ×é·ÖȱʧÐ͵ĵÄСÊ󣬻á³öÏÖѪ¹ÜÑÏÖØÒì³£ÐÔÅßÌ¥ËÀÍö¡£ |

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