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yin198716

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Dll4 is constitutively expressed on the thymic epithelial cells (TEC) as well as on endothelial cells. Specific deletion of Dll4 in thymic epithelial cells throughout development results in a complete block of T-cell development, associated with thymic acellularity and ectopic appearance of immature B cells.
Oncology
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Rio2016

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yin198716: 金币+5, 翻译EPI+1, 有帮助 2013-03-24 15:27:06
Dll4 is constitutively expressed on the thymic epithelial cells (TEC) as well as on endothelial cells.

Dll4在胸腺上皮细胞中持续表达,同样发生于内皮细胞中。

Specific deletion of Dll4 in thymic epithelial cells throughout development results in a complete block of T-cell development, associated with thymic acellularity and ectopic appearance of immature B cells.

在胸腺上皮细胞的整个发育过程中特异性删除Dll4,会导致T细胞发育障碍,还与胸腺无细胞化和非成熟性B细胞形态异常有关。

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2楼2013-03-24 10:09:09
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