这个主要是看你的给药途径和靶细胞靶部位的要求的。如果是一般的口服给药，直接肠道吸收就没有必要做到那个纳米级的了。有点杀猪用牛刀的感觉。但是，如果是静脉注射，那至少应该在你说的6微米以下，不然会很恐怖（这个大家都懂的）另外，当载药系统粒径达到一定程度会出现很多意想不到的效果。比如， avoid the capture of the immune system(T cells, NK cells et al), increase the bioavailability, or even increase the targeting effiency ( if the drugs need to be deliveried to marrow, the diameter should be less than 50nm or even lower. et al) . of course, the increase of surface area can also play a very important role in the capture & absorption of the system..
PS: nanosized particles have lots of advantages, such as surface effect, small size effect,quantum size effect, macroscopic quantum tunneling effect, Quantum tunneling dielectric and the confined effect, which enable nanoscaled particles a very promising direction, not only in medicine, pharmacy, but also in new materials and technology.
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