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【答案】应助回帖
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phu_grassman: 金币+2, thanks 2013-03-09 18:55:22
yunyun89623: 金币+7, 翻译EPI+1, ★★★★★最佳答案 2013-03-12 09:10:15
One characteristic of polymeric nanocarriers of particular importance in the field of pulmonary delivery is the fact that they have appropriate sizes to avoid macrophage clearance in the alveolar region, and may in principle be designed to control the delivery of the therapeutic of interest by either promoting transepithelial transport , or ( the therapeutic of interest) be transported itself (for systemic delivery) , via translocation or transcytosis , or to improve the retention of the API in the lungs in case the target is the lungs (regional delivery).
聚合纳米载体在肺部给药领域一个尤其重要的特性是，事实上它们具有合适的粒径，(因此）可以防止被肺泡区域内的巨噬细胞（吞噬）清除，而且原则上，它们(聚合纳米载体)可以被设计成: 1) 通过提高上皮输运能力可控输运所感兴趣的治疗药物，2) 通过易位转运或胞吞转运作用自行输送治疗药物（系统性输运), 3) 在靶向目标为肺时, 延长API在肺部的停留时间。
P.S.: 现在随着环境的污染，靶向药物治疗肺癌是一个很重要的肺癌治疗手段。楼上加油，根治肺癌靠你了。 |
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