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| Treatment with VEGF inhibitors generally prolongs the survival of responsive patients with cancer of the order of months . Two anti-VEGF compounds — intravitreous injection of the VEGF aptamer pegaptanib ( Macugen) and the anti-VEGF Fab antibody ranibizumab (Lucentis) — have been approved for treatment of the wet (neovascular) form of age-related macular degeneration, which causes blindness owing to the formation of leaky neovessels. Bevacizumab is also used off-label for this condition. |
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