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yin198716新虫 (正式写手)
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1 As noted earlier, pericytes represent a specialized mesenchymal cell type (related to smooth muscle cells) with finger-like projections that wrap around the endothelial tubing of blood vessels. In normal tissues, pericytes are known to provide paracrine support signals to the normally quiescent endothelium. 2 For example, Ang-1 secreted by pericytes conveys antiproliferative stabilizing signals that are received by the Tie2 receptors expressed on the surface of endothelial cells; some pericytes also produce low levels of VEGF that serve a trophic function in endothelial homeostasis. Pericytes also collaborate with the endothelial cells to synthesize the vascular basement membrane that anchors both pericytes and endothelial cells and helps vessel walls to withstand the hydrostatic pressure of blood flow. |
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木虫 (正式写手)
- 翻译EPI: 17
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【答案】应助回帖
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sltmac: 金币+1 2013-01-19 08:46:30
yin198716: 金币+2, 翻译EPI+1, ★有帮助 2013-01-21 14:09:33
sltmac: 金币+1 2013-01-19 08:46:30
yin198716: 金币+2, 翻译EPI+1, ★有帮助 2013-01-21 14:09:33
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1.如前所述，周细胞代表一个专门的间充质细胞类型（与平滑肌细胞相关），具有环绕包裹于血管的内皮管的指状突起。在正常组织中，我们知道周细胞向正常静息内提供旁分泌的支持信号。 2.例如，周细胞分泌的Ang-1，传送所接收的内皮细胞表面上表达的Tie2受体的抗恶性细胞增生稳定信号；一些周细胞也产生为内皮组织自身平衡提供营养机能的低水平VEGF。周细胞与内皮细胞共同协作合成集合周细胞和内皮细胞血管基底膜，并有助于血管壁承受血流量的液体静压。 |
2楼2013-01-18 22:30:18
3楼2013-01-19 10:13:38
