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[求助]
求助日本药典如何定义溶解度的？
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如题：日本药典是如何定义溶解度的，貌似和中过药典不一致？ 可有知道的，求解下~ |
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- 【讨论】药典凡例中溶解度测定法的不明之处
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【答案】应助回帖
感谢参与，应助指数 +1
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跟中国药典是一致的，参见JP16通则。 29. In the section under the heading Description,solubilities are expressed by the terms in Table 2.Unless otherwise specified, solubility means the degree of dissolution of a JP Drug, previously powdered in the case of a solid drug, within 30 minutes in a solvent at 20±59C, by vigorous shaking for 30 seconds each time at 5-minute intervals. Table 2 Descriptive term Volume of solvent required for dissolving 1gor1mLofsolute Very soluble Less than 1 mL Freely soluble From 1 mL to less than 10mL Soluble From 10 mL to less than 30mL Sparingly soluble From 30 mL to less than 10mL Slightly soluble From 100 mL to less than 1000 mL Very slightly soluble From 1000 mL to less than 10000 mL Practically insoluble, or insolu-ble 10000 mL and over |
2楼2012-12-26 14:33:16
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中文描述 英文描述 日文描述 溶解性质 极易溶解 Very soluble 極めて溶やすい ＜1 易溶 Freely soluble 溶けやすい 1to10 溶解 Soluble やや溶けやすい 10to30 略溶 Sparingly soluble やや溶けにくい 30to100 微溶 Slightly soluble 溶けにくい 100to1000 极微溶解 Very slightly soluble 極めて溶けにくい 1000to10,000 几乎不溶或不溶 Practically insoluble, or Insoluble ほとんど溶けない ≥10,000 |
3楼2014-05-22 23:01:07
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