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小木虫论坛-学术科研互动平台 » 化学化工区 » 分析 » 色谱质谱 » 液质正模式分析一个化合物，分子量增加46 会是加了2个钠吗
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yxh-5566

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[求助] 液质正模式分析一个化合物，分子量增加46 会是加了2个钠吗

如题，一个分子上能加两个钠吗
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1楼 2012-12-21 16:03:28
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organicsuper

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crity328: 金币+1, 感谢交流，欢迎常来~ 2012-12-21 21:21:01
yxh-5566: 金币+1, ★★★很有帮助 2012-12-24 12:39:39
加2个Na也可以,但是就要出双电荷峰,即主峰跟同位素峰(也就是M+1)峰之间的间距是0.5m/z.其它的貌似没有46的分子加上去.如果可是溶剂分子,那么去问问做质谱的老师用的是啥溶剂.
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2楼2012-12-21 19:06:35
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lzjessie_wlf

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yxh-5566: 金币+1, ★★★很有帮助 2012-12-24 12:39:57
The 46 difference from your single-charged compound [M+H] normally should come from the formic acid adduct [M+H+HCOOH] since formic acid (or TFA) is added for positive mode in ESI.

Only 22 differentiated from the [M+H] peak if a sodium was added, and 44 differentiated from the [M+H] peak if two sodium were added for single charged peak.
  For double charged peak, the m/z for it should be [M+Na+Na]/2 since two positive charge have been attached.
the difference between isotope pattern should be 0.5 instead of 1 for single charged peak.
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3楼2012-12-21 23:56:09
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zzjcust

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yxh-5566: 金币+1, ★★★很有帮助 2012-12-24 12:40:14
要是加钠是不是带两个电荷了，质荷比就不对了，加甲酸的可能性大一些，
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4楼2012-12-22 07:17:16
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yxh-5566

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2楼: Originally posted by organicsuper at 2012-12-21 19:06:35
加2个Na也可以,但是就要出双电荷峰,即主峰跟同位素峰(也就是M+1)峰之间的间距是0.5m/z.其它的貌似没有46的分子加上去.如果可是溶剂分子,那么去问问做质谱的老师用的是啥溶剂.

谢谢回复
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5楼2012-12-24 12:26:55
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yxh-5566

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3楼: Originally posted by lzjessie_wlf at 2012-12-21 23:56:09
The 46 difference from your single-charged compound  normally should come from the formic acid adduct  since formic acid (or TFA) is added for positive mode in ESI.

Only 22 differentiated from the ...

谢谢
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6楼2012-12-24 12:27:21
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yxh-5566

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4楼: Originally posted by zzjcust at 2012-12-22 07:17:16
要是加钠是不是带两个电荷了，质荷比就不对了，加甲酸的可能性大一些，

哦，多谢
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7楼2012-12-24 12:28:15
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valley_chow

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yxh-5566: 金币+1, ★★★很有帮助 2012-12-26 16:46:10
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3楼: Originally posted by lzjessie_wlf at 2012-12-21 23:56:09
The 46 difference from your single-charged compound  normally should come from the formic acid adduct  since formic acid (or TFA) is added for positive mode in ESI.

Only 22 differentiated from the ...

M+Na就直接是带电荷的离子了，没有多加一个氢了，你用22和44来打比方都是不对的，只有聚乙二醇化合物才会有+22和+44的。
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8楼2012-12-24 12:33:31
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ouyanggan

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3楼: Originally posted by lzjessie_wlf at 2012-12-21 23:56:09
The 46 difference from your single-charged compound  normally should come from the formic acid adduct  since formic acid (or TFA) is added for positive mode in ESI.

Only 22 differentiated from the ...

I also have some problem ，product exact mass is 258，but get ESI(+) result is 304， M+46；if as you said ： [M+H+HCOOH] =M+47，can you explain this？
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9楼2022-08-08 11:32:23
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ouyanggan

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引用回帖:
3楼: Originally posted by lzjessie_wlf at 2012-12-21 23:56:09
The 46 difference from your single-charged compound  normally should come from the formic acid adduct  since formic acid (or TFA) is added for positive mode in ESI.

Only 22 differentiated from the ...

I also have some problem ，product exact mass is 258，but get ESI(+) result is 304， M+46；if as you said ： [M+H+HCOOH] =M+47，can you explain this？
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10楼2022-08-08 11:35:08
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