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【有奖交流】积极回复本帖子，参与交流，就有机会分得作者 east999 的 9 个金币

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east999

木虫 (著名写手)

应助: 0 (幼儿园)
金币: 33919.6
帖子: 2793
在线: 87.6小时
虫号: 45008
注册: 2004-05-08
专业: 药剂学

[交流] [求助]有无南开大学分子生物研究所的战友，请教O-(4-乙氧基-丁基)-小檗胺的合成

一直未找到该合成路线，又无法购买，特求教，谢谢。
一般资料：
O-(4-乙氧基-丁基)-小檗胺
英文名：O-(4-ethoxybutyl)berbamine
分子式：C43H52N2O7
分子量：708.9
CAS：106006-09-1

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1楼 2007-07-18 10:09:34

已阅回复此楼关注TA 给TA发消息送TA红花 TA的回帖

cpucf

铁杆木虫 (知名作家)

相由心生，境随心转

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金币: 6293
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在线: 92.9小时
虫号: 53526
注册: 2004-09-18
专业: 药剂学

★
east999(金币+1):无论结果怎样，谢谢了

所有的结果如下：好像没有合成的报道

Zhu, Huifang; Liu, Jiewen; Qi, Shuling; Pan, Bing; Zhou, Yuan; Qi, Jing; Yang, Chunzheng; Xiong, Dongsheng; Jiang, Wenguo; Cheng, Yanhong; Zhao, Shixuan; Yang, Ming; Zhang, Yongci; Zou, Linglin; Liu, Juanni. Antitumor activity of a berbamine derivative EBB by inhibiting tumor cell invasion and transfer. Faming Zhuanli Shenqing Gongkai Shuomingshu  (2006),    23pp.  CODEN: CNXXEV  CN  1810247  A  20060802  CAN 145:449178  AN 2006:793422 CAPLUS

Pan, Bing; Zhou, Yuan; Qi, Jing; Xiong, Dongsheng; Liu, Jiewen; Qi, Shuling; Cheng, Yanhong; Yang, Chunzheng; Zhu, Huifang. Effect of calmodulin antagonist EBB on invasion of human fibrosarcoma cell HT1080. Zhongguo Yixue Kexueyuan Xuebao  (2005),  27(3),  311-314.  CODEN: CIHPDR  ISSN:1000-503X.  CAN 145:448732  AN

Fang, Bai-Jun; Yu, Mei-Li; Yang, Shao-Guang; Liao, Lian-Ming; Liu, Jie-Wen; Zhao, Robert C.-H. Effect of O-4-ethoxyl-butyl-berbamine in combination with pegylated liposomal doxorubicin on advanced hepatoma in mice. World Journal of Gastroenterology  (2004),  10(7),  950-953.  CODEN: WJGAF2  ISSN:1007-9327.  CAN 141:360283  AN 2004:375259 CAPLUS

Liu, Jiewen; Qi, Shuling; Zhu, Huifang; Zhang, Jinhong; Li, Zhuo; Wang, Tong. The effect of calmodulin antagonist berbamine derivative-EBB on hepatoma in vitro and in vivo. Chinese Medical Journal (Beijing, China, English Edition)  (2002),  115(5),  759-762.  CODEN: CMJODS  ISSN:0366-6999.  CAN 138:83012  AN 2002:500645 CAPLUS

Zhang, Jinhong; Xu, Naihan; Xu, Chang; Chen, Jiatong; Liu, Huijun; Duan, Jiangyan. Preliminary investigation on mechanism of anticancer by berbamine derivative (EEB) in vitro. Xibao Shengwuxue Zazhi  (2001),  23(4),  218-223.  CODEN: XISZD3  ISSN:0253-9977.  CAN 136:363383  AN 2002:61045 CAPLUS

Zheng, Guanghu; Liu, Huazhang. Primary study on effect and mechanisms of hypotension of central calcium in rabbits. Guangdong Yaoxueyuan Xuebao  (1999),  15(1),  10-12.  CODEN: GYXUF8  CAN 131:139199  AN 1999:280049 CAPLUS

Zheng, Guang-Hua; Cheng, Zhong-Lun; Jiang, Jia-Hua. Effects of O-(4-ethoxybutyl)berbamine on isolated frog hearts. Zhongguo Yaoli Xuebao  (1998),  19(5),  497-500.  CODEN: CYLPDN  ISSN:0253-9756.  CAN 129:298193  AN 1998:595115 CAPLUS

Zhang, Jinhong; Duan, Hongyan; Gen, Zhaohui; Chen, Jiatong; Huang, Jianyin; Li, Xi. Study on the effects of berbamine and its derivatives on proliferation of Bowes cells in vitro. Zhongcaoyao  (1997),  28(8),  483-485.  CODEN: CTYAD8  ISSN:0253-2670.  CAN 128:252608  AN 1998:126131 CAPLUS

Wang, Chen-Guang; Ge, Uue-Ping; Chen, Zun-Qi; He, Qi-Yang; Zhang, Hong-Qing. Reversal of resistance of HL60/Har cells to anti-tumor drugs by calmodulin antagonist. Zhongguo Bingli Shengli Zazhi  (1995),  11(5),  496-9.  CODEN: ZBSZEB  ISSN:1000-4718.  CAN 124:219626  AN 1996:112957 CAPLUS

Liu, Weimin; Zhao, Shixuan; Liu, Jiewen. Inhibitory effects of calmodulin antagonist EBB on cultured fibroblast. Zhongguo Yaolixue Tongbao  (1992),  8(5),  374-6.  CODEN: ZYTOE8  ISSN:1001-1978.  CAN 118:247585  AN 1993:247585 CAPLUS

Zhang, Suipo; Xu, Youhan. Inhibition of the activities of calmodulin-dependent calcium, magnesium- ATPase by benzylisoquinolines:  structure-activity relationships. Shengwu Huaxue Yu Shengwu Wuli Xuebao  (1988),  20(1),  13-20.  CODEN: SHWPAU  ISSN:0582-9879.  CAN 109:124847  AN 1988:524847 CAPLUS

Xu, Youhan; Liu, Jian; Zhang, Suipo; Liu, Lisheng. The effect of berbamine derivatives on activated calcium-stimulated magnesium-dependent ATPase in erythrocyte membranes. Biochemical Journal  (1987),  248(3),  985-8.  CODEN: BIJOAK  ISSN:0306-3275.  CAN 108:16311  AN 1988:16311 CAPLUS

Xu, Youhan; Zhang, Suipo. A derivative of bisbenzylisoquinoline alkaloid is a new and potential calmodulin antagonist. Biochemical and Biophysical Research Communications  (1986),  140(1),  461-7.  CODEN: BBRCA9  ISSN:0006-291X.  CAN 106:27670  AN 1987:27670 CAPLUS

Cheng Yan-hong; Qi Jing; Xiong Dong-sheng; Liu Jie-wen; Qi Shu-ling; Pan Bing; Yang Chun-zheng; Zhu Hui-fang Reversal of multidrug resistance in drug-resistant human breast cancer cell line MCF-7/ADR by calmodulin antagonist O-(4-ethoxyl-butyl)-berbamine. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae  (2006),  28(2),  164-8.  Journal code: 8006230.  ISSN:1000-503X.  PubMed ID 16733896 AN 2006306455 MEDLINE

Pan Bing; Zhou Yuan; Qi Jing; Xiong Dong-sheng; Liu Jie-wen; Qi Shu-ling; Cheng Yan-hong; Yang Chun-zheng; Zhu Hui-fang Effect of calmodulin antagonist EBB on invasion of human fibrosarcoma cell HT1080. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae  (2005),  27(3),  311-4.  Journal code: 8006230.  ISSN:1000-503X.  PubMed ID 16038266 AN 2005380752 MEDLINE

Fang Bai-Jun; Yu Mei-Li; Yang Shao-Guang; Liao Lian-Ming; Liu Jie-Wen; Zhao Robert C-H Effect of O-4-ethoxyl-butyl-berbamine in combination with pegylated liposomal doxorubicin on advanced hepatoma in mice. World journal of gastroenterology : WJG  (2004),  10(7),  950-3.  Journal code: 100883448.  ISSN:1007-9327.  PubMed ID 15052672 AN 2004187605 MEDLINE

Liu Jiewen; Qi Shuling; Zhu Huifang; Zhang Jinhong; Li Zhuo; Wang Tong The effect of calmodulin antagonist berbaminederivative-EBB on hepatoma in vitro and in vivo. Chinese medical journal  (2002),  115(5),  759-62.  Journal code: 7513795.  ISSN:0366-6999.  PubMed ID 12133551 AN 2002383504 MEDLINE

Zheng G H; Chen Z L; Jiang J H Effects of O-(4-ethoxyl-butyl)-berbamine on isolated frog hearts. Zhongguo yao li xue bao = Acta pharmacologica Sinica  (1998),  19(5),  497-500.  Journal code: 8100330.  ISSN:0253-9756.  PubMed ID 10375820 AN 1999304108 MEDLINE

Xu Y H; Liu J; Zhang S P; Liu L H The effect of berbamine derivatives on activated Ca2+-stimulated Mg2+-dependent ATPase in erythrocyte membranes. The Biochemical journal  (1987),  248(3),  985-8.  Journal code: 2984726R.  ISSN:0264-6021.  PubMed ID 2963623 AN 88133976 MEDLINE

Xu Y H; Zhang S P A derivative of bisbenzylisoquinoline alkaloid is a new and potential calmodulin antagonist. Biochemical and biophysical research communications  (1986),  140(1),  461-7.  Journal code: 0372516.  ISSN:0006-291X.  PubMed ID 3022722 AN 87048786 MEDLINE