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Layer-by-layer (LbL) self-assembly can construct ultra thin films via alternate adsorption of oppositely charged polyions, nanoparticles, and biomolecules.The obtained films have thicknesses in the nanometer range and tunable properties to their surroundings, such as permeability, solubility, and morphology.1–6 The use of LbL nanoassembled multilayers as drug carrier systems has been studied widely by a number of research groups.T ypically, drugs were loaded in polyelectrolyte nanocapsules, where adjustable, self-assembled, multilayer walls served as diffusion barriers giving hours release time. The procedure was useful for drugs that do not aggregate and lose their potency at higher concentrations.Less attention was given to the inclusion of drug molecules as an intrinsic component of the multilayers by alternating the assembly of the drug molecules with oppositely charged polyelectrolytes.Such an approach could avoid the preparation of highly concentrated drug suspensions. Being tightly bound within the polyelectrolyte multilayers, such drug molecules could be released much slower in a sustained fashion, thus retaining their biological activity. Dif ferent kinds of dye molecules (indoine blue, chromotrope 2R, methylene blue, rhodamine 6G), as well as plasmid DNA induced in the polyelectrolyte multilayers, have been investigated for their release according to varying environmental conditions. Numerous studies havebeen concentrated on the stability of self-assembled polyelectrolyte layers on either planar or spherical surfaces; and further studies have been directed to the possibility of assembling drugs directly in the polyelectrolyte layers for delivery.The polyelectrolyte layers can prevent peptide degradation through proteolysis, and can serve as a storage device. |
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2楼2012-12-11 19:23:58
sklyer_123
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sltmac: 如发现再有机器翻译将禁言 2013-02-21 09:17:21
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逐层（淋巴瘤）自组装可以建造超 薄膜通过交替吸附生地被控 聚离子，纳米粒子，和生物分子的获得。 薄膜厚度在纳米范围内可调 性能的环境，如渗透率， 溶解度，和形态。1–6使用层层nanoassembled 多层膜作为药物载体系统进行了研究 广泛的一些研究团体。不ypically， 药被装在聚电解质微胶囊，其中 可调，自组装，多层壁担任扩散 障碍给予小时释放时间。本 程序是有用的药物，不累计和 失去其效力，在较高浓度的关注较少。 被列入药物分子 一个内在的组成部分的多层交替 大会的药物分子与相反 电荷的聚电解质。这种方法可避免 制备浓缩药物悬浮液。 被紧紧束缚在聚电解质多层膜， 这种药物分子可以释放慢得多 一个持续的方式，从而保持其生物活性。 不同种类的染料分子（indoine蓝色，变色 受体，亚甲基蓝，罗丹明R6G），以及 质粒脱氧核糖核酸诱导的聚电解质多层膜， 研究了他们的释放根据不同 环境条件。无数的研究已经集中在稳定的自组装聚电解质 层平面或球面； 进一步的研究已指示的可能性 组合药物直接在电解质层 交货。聚电解质层可防止肽 降解的蛋白质，并可以作为一个存储 装置。 分享到 翻译结果重试 抱歉，系统响应超时，请稍后再试 支持中英、中日在线互译 支持网页翻译，在输入框输入网页地址即可 提供一键清空、复制功能、支持双语对照查看，使您体验更加流畅  |
3楼2012-12-25 22:31:18
